T. Thorsen

TL;DR: Survival analyses on a subcohort of patients with locally advanced breast cancer uniformly treated in a prospective study showed significantly different outcomes for the patients belonging to the various groups, including a poor prognosis for the basal-like subtype and a significant difference in outcome for the two estrogen receptor-positive groups.

TL;DR: Androgen receptor levels were strongly correlated to estrogen and progesterone receptor concentration in both primary and secondary cancers, supporting the view that some of the beneficial effects of high dose progestin treatment of advanced breast cancer are mediated through the androgen receptor.

TL;DR: Both body weight and Quetelet's index were significantly related to tumour diameter in older patients with hormone receptor negative tumours, and body size was positively related to hormone receptor status and to diameter of the primary tumour.

TL;DR: It is concluded that growth stimulation of MCF-7 cells by long term treatment with oestradiol may be mediated through autocrine secretion of IGF-I, and the effect of short term stimulation of thymidine incorporation suggest that the growth response of ostradiol is more complex, and indicate that a cooperative interaction with IGF- I is involved, which is unrelated to stimulated Autocrine secretion.

TL;DR: No significant difference in cytosol oestradiol concentration was found in receptor-positive and negative pre- and postmenopausal women, which would indicate that factors other than plasma levels influence tissue availability of ostradiol.