T
Tack-Ki Leung
Researcher at Montreal Heart Institute
Publications - 21
Citations - 1418
Tack-Ki Leung is an academic researcher from Montreal Heart Institute. The author has contributed to research in topics: Atrial fibrillation & Angioplasty. The author has an hindex of 11, co-authored 21 publications receiving 1358 citations. Previous affiliations of Tack-Ki Leung include Université de Montréal.
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Journal ArticleDOI
Evolution of the atrial fibrillation substrate in experimental congestive heart failure: angiotensin-dependent and -independent pathways.
Sophie Cardin,Danshi Li,Danshi Li,Nathalie Thorin-Trescases,Tack-Ki Leung,Tack-Ki Leung,Eric Thorin,Eric Thorin,Stanley Nattel,Stanley Nattel,Stanley Nattel +10 more
TL;DR: AC inhibition prevented increases in tissue angiotensin II concentration, phosphorylated ERK expression, Bax/Bcl-2 ratio, and cellular apoptosis, but did not affect total cell death, leukocyte infiltration, JNK or p38 activation, and reduced butdid not eliminate tissue fibrosis.
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Differences in atrial versus ventricular remodeling in dogs with ventricular tachypacing-induced congestive heart failure
TL;DR: There are qualitative and quantitative differences in atrial versus ventricular remodeling in experimental ventricular tachypacing-induced CHF, with potentially important consequences for understanding underlying mechanisms and developing new therapeutic approaches.
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Dynamic nature of atrial fibrillation substrate during development and reversal of heart failure in dogs.
TL;DR: Reversal of CHF is followed by normalized atrial function and decreased duration of AF; however, fibrosis and conduction abnormalities are not reversible, and a substrate that can support prolonged AF remains.
Journal ArticleDOI
Effects of simvastatin on the development of the atrial fibrillation substrate in dogs with congestive heart failure
Akiko Shiroshita-Takeshita,Bianca J. J. M. Brundel,Brett Burstein,Brett Burstein,Tack-Ki Leung,Hideo Mitamura,Satoshi Ogawa,Stanley Nattel,Stanley Nattel +8 more
TL;DR: CHF-induced atrial structural remodeling and AF promotion are attenuated by simvastatin, but not fenofibrate, and Statin-induced inhibition of profibrotic atrial fibroblast responses and attenuation of left-ventricular dysfunction may contribute to preventing the CHF- induced fibrotic AF substrate.
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Ionic current abnormalities associated with prolonged action potentials in cardiomyocytes from diseased human right ventricles
TL;DR: I(K1, I(to1), and I(Ks) are down-regulated in AH cells of human heart failure, which contributes to APD prolongation that favors the occurrence of arrhythmogenic EADs and suggests a link between human cardiac histopathologic/functional abnormalities and arrh rhythmogenic ionic remodeling.