Tadataka Yamada

TL;DR: The regional distribution and chromatographic characteristics of somatostatin-like immunoreactivity (SLI) were studied in autopsy specimens of 8 human brains and the effects of temperature and time lapse between death and tissue extraction on SLI concentration and Chromatographic pattern in rat brain were examined.

TL;DR: The hypothesis that brain peptides, acting locally in the brain as neuromodulators, play an important role in the genesis of the syndromes of morphine addiction and withdrawal is supported.

TL;DR: PTU, independent of its antithyroid effect, diminishes hepatic macromolecular covalent binding of acetaminophen reactive metabolite both in vivo and in vitro, and it does so by detoxifying the reactive metabolITE through direct chemical interaction in a manner similar to GSH.

TL;DR: Inhibitory kinetics suggested that sulphobromophthalein and Rose Bengal were non-competitive inhibitors of glutathione S-transferase activities when 1-chloro-2,4-dinitrobenzene was used as substrate for both PLAT Y(1) and PLATY(2), which showed higher affinities for glutathion than those of Rose Bengal and 1-anilino-8-naphthalenesulphonate.

TL;DR: The binding of ethacrynic acid to the glutathione S -transferases is characterized and the selectivity of this binding is delineated to represent a unique example of covalent binding of a drug to the metabolizing enzyme without prior microsomal enzyme activation.