T
Tadatoshi Hashimoto
Researcher at Kumamoto University
Publications - 5
Citations - 105
Tadatoshi Hashimoto is an academic researcher from Kumamoto University. The author has contributed to research in topics: Pipecolic acid & gamma-Aminobutyric acid. The author has an hindex of 3, co-authored 5 publications receiving 99 citations.
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Electrophoretic study of pipecolic acid, a biogenic imino acid, in the mammalian brain
TL;DR: It is reported that PA inhibits the uptake of GABA into the brain slices and enhances the release of GABA from the slices, and it is likely that the inhibitory response due to PA may have some connections with GABAergic transmission.
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Pipecolic acid: a new type of alpha-amino acid possessing bicuculline-sensitive action in the mammalian brain.
Kazuo Takahama,Takeshi Miyata,Tadatoshi Hashimoto,Yoshiro Okano,Taizo Hitoshi,Yoshitoshi Kasé +5 more
TL;DR: Using unit recording and electrophoretic techniques, pharmacological properties of pipecolic acid were studied in the brain neurons of rats and suggest that PA might be a new type of substance possessing bicuculline-sensitive action.
Journal ArticleDOI
Pipecolic acid enhancement of GABA response in single neurons of rat brain
Kazuo Takahama,Tadatoshi Hashimoto,M.-W. Wang,N. Akaike,Taizo Hitoshi,Yoshiro Okano,Yoshitoshi Kasé,Takeshi Miyata +7 more
TL;DR: Using unit recording and microelectrophoresis, influence of pipecolic acid (PA) on GABA and glycine responses was studied in the cerebral cortical and hippocampal pyramidal neurons of rats as discussed by the authors.
Journal ArticleDOI
Piperidine: a microelectrophoretic study in the mammalian brain.
Kazuo Takahama,K. Satoh,Jun Kaisaku,Tadatoshi Hashimoto,N. Akaike,Yoshiro Okano,Yoshitoshi Kasé,Takeshi Miyata +7 more
TL;DR: Using unit recording and electrophoretic techniques, the action of piperidine on unit activity of the brain of the rat was studied and the actions of p Piperidine were blocked by tetraethylammonium but not by scopolamine.