T
Takahiro Yamanaka
Researcher at Gunma University
Publications - 52
Citations - 792
Takahiro Yamanaka is an academic researcher from Gunma University. The author has contributed to research in topics: Hepatectomy & Medicine. The author has an hindex of 10, co-authored 46 publications receiving 563 citations.
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Journal ArticleDOI
Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinoma
Norifumi Harimoto,Ken Shirabe,Y. Yamashita,Toru Ikegami,Tomoharu Yoshizumi,Yuji Soejima,Tetsuo Ikeda,Yoshihiko Maehara,Akihiro Nishie,Takahiro Yamanaka +9 more
TL;DR: This study investigated the effect of sarcopenia on short‐ and long‐term outcomes following partial hepatectomy for hepatocellular carcinoma (HCC), and aimed to identify prognostic factors.
Journal ArticleDOI
Nintedanib inhibits intrahepatic cholangiocarcinoma aggressiveness via suppression of cytokines extracted from activated cancer-associated fibroblasts
Takahiro Yamanaka,Norifumi Harimoto,Takehiko Yokobori,Ryo Muranushi,Kouki Hoshino,Kei Hagiwara,Dolgormaa Gantumur,Tadashi Handa,Norihiro Ishii,Mariko Tsukagoshi,Takamichi Igarashi,Hiroshi Tanaka,Akira Watanabe,Norio Kubo,Kenichiro Araki,Ken Shirabe +15 more
TL;DR: The findings suggest that therapeutic strategies combining conventional cytotoxic agents with nintedanib targeting CAFs are promising for overcoming refractory ICC with activated CAFs.
Journal ArticleDOI
Association of RAB5 overexpression in pancreatic cancer with cancer Progression and poor prognosis via E-cadherin suppression
Takamichi Igarashi,Kenichiro Araki,Takehiko Yokobori,Bolag Altan,Takahiro Yamanaka,Norihiro Ishii,Mariko Tsukagoshi,Akira Watanabe,Norio Kubo,Tadashi Handa,Yasuo Hosouchi,Masahiko Nishiyama,Tetsunari Oyama,Ken Shirabe,Hiroyuki Kuwano +14 more
TL;DR: RAB5 contributes to poor prognosis and progression in Pancreatic cancer patients and may be a promising candidate for individualized therapy in refractory pancreatic cancer.
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D-dimer predicts postoperative recurrence and prognosis in patients with liver metastasis of colorectal cancer.
Akira Watanabe,Kenichiro Araki,N. Harimoto,Norio Kubo,Takamichi Igarashi,Norihiro Ishii,Takahiro Yamanaka,Kei Hagiwara,Hiroyuki Kuwano,Ken Shirabe +9 more
TL;DR: D-dimer may help predict recurrence and prognosis in patients with CRLM and was an independent prognostic factor of RFS, a major metastatic site for colorectal cancer.
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Conophylline suppresses pancreatic cancer desmoplasia and cancer-promoting cytokines produced by cancer-associated fibroblasts.
Norihiro Ishii,Kenichiro Araki,Takehiko Yokobori,Kei Hagiwara,Dorgormaa Gantumur,Takahiro Yamanaka,Tadashi Handa,Mariko Tsukagoshi,Takamichi Igarashi,Akira Watanabe,Norio Kubo,Norifumi Harimoto,Atsushi Masamune,Kazuo Umezawa,Hiroyuki Kuwano,Ken Shirabe +15 more
TL;DR: It is shown that cancer‐associated fibroblasts (CAF) stimulated indicators of pancreatic cancer malignancy, such as proliferation, invasiveness, and chemoresistance, and that CnP suppressed CAF activity and proliferation, and inhibited the stimulating effects of CAF on pancreatic cancers cells.