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Atsushi Masamune
Researcher at Tohoku University
Publications - 522
Citations - 13741
Atsushi Masamune is an academic researcher from Tohoku University. The author has contributed to research in topics: Medicine & Pancreatitis. The author has an hindex of 60, co-authored 403 publications receiving 11135 citations. Previous affiliations of Atsushi Masamune include University of Washington.
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Journal ArticleDOI
Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy
Mara H. Sherman,Ruth T. Yu,Dannielle D. Engle,Ning Ding,Annette R. Atkins,Hervé Tiriac,Eric A. Collisson,Frances Connor,Terry Van Dyke,Serguei Kozlov,Philip Martin,Tiffany W. Tseng,David W. Dawson,Timothy R. Donahue,Atsushi Masamune,Tooru Shimosegawa,Minoti V. Apte,Jeremy S. Wilson,Beverly Ng,Beverly Ng,Sue Lynn Lau,Sue Lynn Lau,Sue Lynn Lau,Jenny E. Gunton,Geoffrey M. Wahl,Tony Hunter,Jeffrey A. Drebin,Peter J. O'Dwyer,Christopher Liddle,David A. Tuveson,Michael Downes,Ronald M. Evans,Ronald M. Evans +32 more
TL;DR: It is shown that VDR acts as a master transcriptional regulator of PSCs to reprise the quiescent state, resulting in induced stromal remodeling, increased intratumoral gemcitabine, reduced tumor volume, and a 57% increase in survival compared to chemotherapy alone.
Journal ArticleDOI
StellaTUM: current consensus and discussion on pancreatic stellate cell research
Mert Erkan,Guido Adler,Minoti V. Apte,Max G. Bachem,Malte Buchholz,Sönke Detlefsen,Irene Esposito,Helmut Friess,Thomas M. Gress,Hans Joerg Habisch,Rosa F. Hwang,Robert Jaster,Jörg Kleeff,Günter Klöppel,Claus Kordes,Craig D. Logsdon,Atsushi Masamune,Christoph W. Michalski,Junseo Oh,Phoebe A. Phillips,Massimo Pinzani,Carolin Reiser-Erkan,Hidekazu Tsukamoto,Jeremy S. Wilson +23 more
TL;DR: Members of the Pancreatic Star Alliance discuss and consolidate current knowledge to outline and delineate areas of consensus or otherwise (eg, with regard to methodological approaches) and, more importantly, to identify essential directions for future research.
Journal ArticleDOI
Expression of survivin is correlated with cancer cell apoptosis and is involved in the development of human pancreatic duct cell tumors.
Kennichi Satoh,Kenzo Kaneko,Morihisa Hirota,Atsushi Masamune,Akihiko Satoh,Tooru Shimosegawa +5 more
TL;DR: This work has shown that survivin, a new member of the inhibitor of apoptosis family of antiapoptotic proteins, was expressed selectively in all the most common human carcinomas but not in normal adult tissues.
Journal ArticleDOI
Variants in CPA1 are strongly associated with early onset chronic pancreatitis
Heiko Witt,Sebastian Beer,Jonas Rosendahl,Jian-Min Chen,Jian-Min Chen,Giriraj R. Chandak,Atsushi Masamune,Melinda Bence,Richárd Szmola,Richárd Szmola,Grzegorz Oracz,Milan Macek,Eesh Bhatia,Sandra Steigenberger,Denise Lasher,Florence Bühler,Catherine Delaporte,Johanna Tebbing,Maren Ludwig,Claudia Pilsak,Karolin Saum,Peter Bugert,Emmanuelle Masson,Emmanuelle Masson,Sumit Paliwal,Seema Bhaskar,Agnieszka Sobczynska-Tomaszewska,Daniel Bak,Ivan Balascak,Gourdas Choudhuri,D. Nageshwar Reddy,G Venkat Rao,Varghese Thomas,Kiyoshi Kume,Eriko Nakano,Yoichi Kakuta,Tooru Shimosegawa,Lukasz Durko,András Szabó,Andrea Schnúr,Andrea Schnúr,Péter Hegyi,Zoltán Rakonczay,Roland H. Pfützer,Alexander Schneider,David A. Groneberg,Markus Braun,Hartmut Schmidt,Ulrike Witt,Helmut Friess,Hana Algül,Olfert Landt,Markus Schuelke,Renate Krüger,Bertram Wiedenmann,Frank Schmidt,Klaus Peter Zimmer,Peter Kovacs,Michael Stumvoll,Matthias Blüher,Thomas Müller,Andreas R. Janecke,Niels Teich,Robert Grützmann,Hans Ulrich Schulz,Joachim Mössner,Volker Keim,Matthias Löhr,Claude Férec,Claude Férec,Miklós Sahin-Tóth +70 more
TL;DR: The mechanism by which CPA1 variants confer increased pancreatitis risk may involve misfolding-induced endoplasmic reticulum stress rather than elevated trypsin activity, as is seen with other genetic risk factors for this disease.
Journal ArticleDOI
Roles of Pancreatic Stellate Cells in Pancreatic Inflammation and Fibrosis
TL;DR: Because PSCs are very similar to hepatic stellate cells, PSC research should develop in directions more relevant to the pathophysiology of the pancreas, for example, issues related to trypsin, non-oxidative alcohol metabolites, and pancreatic cancer.