Takahiro Yano

TL;DR: Serial biopsies from 34 patients with follicular lymphomas that underwent histologic transformation, for abnormalities of the p53 tumor suppressor gene by a combination of immunohistochemistry, single strand conformation polymorphism analysis (SSCP), and sequencing suggest that p53 positive low-grade lymphomas are at risk for progression and that in this subset, aggressive therapy may be warranted.

TL;DR: The presence of MYC rearrangements in a small fraction of progressed aggressive lymphomas, and not in the corresponding antecedent follicular lymphoma, suggests that acquisition of a MYC reshaping is in some cases associated with the transformation event.

TL;DR: In this paper, the authors used restriction fragment analysis, the Southern blot technique, and probes to assess the configuration of the T-cell receptor β, γ, and δ chain genes and the immunoglobulin heavy and K light chain genes.

TL;DR: LAZ3 rearrangements occur in a significant fraction of de novo DAL as well as in a smaller subset of indolent and transformed follicular lymphomas and mutation of the LAZ3 gene does not contribute to its putative oncogenic role in most 3q27 translocated B-cell lymphomas.

TL;DR: This study correlated cytogenetic, histopathologic, molecular, and clinical parameters of 325 cytogenetically analyzed non-Hodgkin's lymphoma patients studied over the past decade to find patients with low-grade lymphomas were as likely as patients with intermediate- or high- grade lymphomas to acquire new chromosomal abnormalities with time to acquire these abnormalities.