T
Takao Sanaki
Researcher at Hokkaido University
Publications - 25
Citations - 684
Takao Sanaki is an academic researcher from Hokkaido University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 8, co-authored 14 publications receiving 180 citations. Previous affiliations of Takao Sanaki include Tohoku University.
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Journal ArticleDOI
Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19
Yuto Unoh,Shota Uehara,Kenji Nakahara,Haruaki Nobori,Y. Yamatsu,S. Yamamoto,Y. Maruyama,Yoshiyuki Taoda,Koji Kasamatsu,Takahiro Suto,Kensuke Kouki,Atsufumi Nakahashi,Sho Kawashima,Takao Sanaki,Shinsuke Toba,Kentaro Uemura,Tohru Mizutare,Shigeru Ando,Michihito Sasaki,Yasuko Orba,Hirofumi Sawa,Akihiko Sato,Takafumi Sato,Teruhisa Kato,Yuki Tachibana +24 more
TL;DR: S-217622 exhibited antiviral activity in vitro against current outbreaking SARS-CoV-2 variants and showed favorable pharmacokinetic profiles in vivo for once-daily oral dosing, indicating that this novel noncovalent inhibitor could be a potential oral agent for treating COVID-19.
Journal ArticleDOI
SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells.
Michihito Sasaki,Kentaro Uemura,Akihiko Sato,Shinsuke Toba,Takao Sanaki,Katsumi Maenaka,William W. Hall,William W. Hall,William W. Hall,Yasuko Orba,Hirofumi Sawa,Hirofumi Sawa +11 more
TL;DR: In this paper, the authors examined the properties of SARS-CoV-2 variants with mutations at the S protein cleavage site that undergo inefficient proteolytic cleavage.
Posted ContentDOI
SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells
Michihito Sasaki,Kentaro Uemura,Akihiko Sato,Shinsuke Toba,Takao Sanaki,Katsumi Maenaka,William W. Hall,William W. Hall,William W. Hall,Yasuko Orba,Hirofumi Sawa,Hirofumi Sawa +11 more
TL;DR: It is demonstrated that the S protein polybasic cleavage motif is a critical factor underlying SARS-CoV-2 entry and cell tropism and researchers should be alert to the possibility of de novo S gene mutations emerging in tissue-culture propagated virus strains.
Journal ArticleDOI
Contribution of synovial macrophages to rat advanced osteoarthritis pain resistant to cyclooxygenase inhibitors.
Yusuke Sakurai,Masahide Fujita,Shiori Kawasaki,Takao Sanaki,Takeshi Yoshioka,Kenichi Higashino,Soichi Tofukuji,Sosuke Yoneda,Tatsuya Takahashi,Ken Koda,Toshiyuki Asaki,Minoru Hasegawa,Yasuhide Morioka +12 more
TL;DR: Data suggest the involvement of synovial macrophages in advanced knee OA pain resistant to COX inhibitors by increasing proinflammatory mediators, and that drugs targeting synovials might have potent analgesic effects.
Journal ArticleDOI
TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein.
Mai Kishimoto,Kentaro Uemura,Takao Sanaki,Akihiko Sato,William W. Hall,Hiroaki Kariwa,Yasuko Orba,Hirofumi Sawa,Hirofumi Sawa,Michihito Sasaki +9 more
TL;DR: In this article, the role of other transmembrane serine proteases (TTSPs) on the replication of SARS-CoV-2 remains to be elucidated.