T
Takashi Okamura
Researcher at Otsuka Pharmaceutical
Publications - 16
Citations - 293
Takashi Okamura is an academic researcher from Otsuka Pharmaceutical. The author has contributed to research in topics: Adenosine A3 receptor & Derivative (chemistry). The author has an hindex of 7, co-authored 16 publications receiving 290 citations.
Papers
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Journal ArticleDOI
Structure-activity relationships of adenosine A3 receptor ligands: new potential therapy for the treatment of glaucoma.
Takashi Okamura,Yasuhisa Kurogi,Kinji Hashimoto,Seiji Sato,Hiroshi Nishikawa,Kimio Kiryu,Yoshimitsu Nagao +6 more
TL;DR: Structure-activity relationships of fused 1,2,4-triazolo[1,5-c ]pyrimidine were performed and compound 1c (OT-7999) was found to significantly decrease intraocular pressure in the animal model.
Patent
Pyrazolo(1,5-a)pyrimidine derivative
TL;DR: A pyrazolo[1,5-a]pyrimidine derivative represented by general formula (1) and having such a potent analgesic effect that it is useful as an analgesic, wherein R1 represents hydrogen, lower alkyl, cycloalkyl, thienyl, furyl, etc..
Journal ArticleDOI
Discovery of novel mesangial cell proliferation inhibitors using a three-dimensional database searching method.
Yasuhisa Kurogi,Kazuyoshi Miyata,Takashi Okamura,Kinji Hashimoto,Kazuhiko Tsutsumi,Masahiro Nasu,Matsuko Moriyasu +6 more
TL;DR: Interestingly, the newly identified compounds by the 3D database searching method exhibited the reduced inhibition of normal proximal tubular epithelial cell proliferation compared to a training set of compounds.
Journal ArticleDOI
1,2,4-Triazolo[5,1-i]purine derivatives as highly potent and selective human adenosine A(3) receptor ligands.
Takashi Okamura,Yasuhisa Kurogi,Hiroshi Nishikawa,Kinji Hashimoto,Hiroshi Fujiwara,Yoshimitsu Nagao +5 more
TL;DR: Novel 1,2,4-triazolo[5,1-i]purine derivatives showing human adenosine A(3) receptor affinities are found and there was a mild parabolic relationship between the length of alkyl groups at the 5-position and the affinITIES at the A(2A) receptor.
Journal ArticleDOI
Facile synthesis of fused 1,2,4-triazolo[1,5-c]pyrimidine derivatives as human adenosine A3 receptor ligands.
TL;DR: This synthetic method was useful in finding new tricyclic adenosine A(3) receptor antagonists and also in diversifying the substituents at two positions on the fused triazolopyrimidine ring.