Patent
Pyrazolo(1,5-a)pyrimidine derivative
Reads0
Chats0
TLDR
A pyrazolo[1,5-a]pyrimidine derivative represented by general formula (1) and having such a potent analgesic effect that it is useful as an analgesic, wherein R1 represents hydrogen, lower alkyl, cycloalkyl, thienyl, furyl, etc..Abstract:
A pyrazolo[1,5-a]pyrimidine derivative represented by general formula (1) and having such a potent analgesic effect that it is useful as an analgesic, wherein R1 represents hydrogen, lower alkyl, cycloalkyl, thienyl, furyl, lower alkenyl or phenyl; R2 represents naphthyl, cycloalkyl, furyl, thienyl, pyridyl, phenoxy or phenyl; R3 represents hydrogen, phenyl or lower alkyl; R4 represents hydrogen, lower alkyl, lower alkoxy-carbonyl, phenyl-substituted lower alkyl, phenyl or halogen; R5 represents hydrogen or lower alkyl; R6 represents hydrogen, lower alkyl, phenyl-substituted lower alkyl or benzoyl; Q represents carbonyl or sulfonyl; A represents a single bond, lower alkylene or lower alkenylene; and n represents 0 or 1.read more
Citations
More filters
Patent
Cannabinoid receptor ligands and uses thereof
TL;DR: In this paper, the compounds of Formula (I) act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described.
Patent
Pyrazolopyrimidines as cyclin dependent kinase inhibitors
Timothy J. Guzi,Kamil Paruch,Michael P. Dwyer,Doll Ronald J,Viyyoor M. Girijavallabhan,Dillard Lawrence W,Vinh D. Tran,Zhen Min He,Ray Anthony James,Haengsoon Park +9 more
TL;DR: In this paper, a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds and methods of treatment, prevention, inhibition, or amelioration of diseases associated with the CDKs using such compounds or pharmaceutical compositions are described.
Patent
Pyrazolopyrimidines as protein kinase inhibitors
TL;DR: In this article, a novel class of pyrazolo[1,5a]pyrimidine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinase using such compounds or pharmaceutical compositions.
Patent
Azolo triazines and pyrimidines
TL;DR: Corticotropin releasing factor (CRF) antagonists of formula (I) or (II) and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress as discussed by the authors.
Patent
Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
TL;DR: In this paper, a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds and methods of treatment, prevention, inhibition, or amelioration of diseases associated with the CDKs using such compounds or pharmaceutical compositions are described.
References
More filters
Patent
4-amino(alkyl)cyclohexane-1-carboxamide compound and use thereof
M. Yoshitomi Pharmaceutical Ind. Ltd. Arita,T. Yoshitomi Pharmaceutical Ind. Ltd. Saito,H. Yoshitomi Pharmaceutical Ind. Ltd. Okuda,Hiroyuki Sato,M. Yoshitomi Pharmaceutical Ind. Ltd. Uehata +4 more
TL;DR: A 4-amino(alkyl)cyclohexane-1-carboxamide compound represented by general formula (I), an isomer thereof, and a pharmaceutically acceptable acid addition salt thereof, wherein each symbol is as defined in the specification.
PatentDOI
Vibration isolation system
TL;DR: In this paper, a vibration isolation system for a cover mountable on a vibratable engine includes a plurality of resilient grommets positioned about stripper bolts which are inserted into the cover and through a resilient sealing gasket to threadedly secure the cover to the engine.
Patent
Coupler for photographic use
Kimie Tachibana,Yutaka Kaneko +1 more
TL;DR: A cyan color-forming coupler for photographic use is described in this article, where the coupler has improved fastness for heat, humidity, and has a chemical structure represented by the following Formula I; where Z is a group of non-metal atoms necessary for completing a nitrogen-containing six-member heterocyclic ring condensed with the pyrazole ring.
Patent
PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVE AND ANTI-INFLAMMATORY CONTAINING THE SAME.
TL;DR: In this article, the authors presented a general formula for pyridine derivatives, where each pyridyl or phenyl may be substituted with one to three groups selected from among hydroxy and lower alkyl, or alternatively R7 and R8 may be combined to form, together with the nitrogen atom to which they are bound.
Patent
Fused pyrimidine compounds and their use as pharmaceuticals
TL;DR: In this paper, azolo-fused pyrimidine compounds having the formula "STR1##" were defined, in which the pyridine ring was fused with the azolo ring.