T
Takashi Yamamura
Researcher at University of Tokyo
Publications - 13
Citations - 1686
Takashi Yamamura is an academic researcher from University of Tokyo. The author has contributed to research in topics: Natural killer T cell & Antigen. The author has an hindex of 8, co-authored 13 publications receiving 1624 citations.
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Functionally Distinct Subsets of CD1d-restricted Natural Killer T Cells Revealed by CD1d Tetramer Staining
TL;DR: The results show that the various activities of CD1d-restricted T cells in tumor rejection, autoimmune disease, and microbial infections could result from activation of functionally distinct subsets, and that inflammatory and antigenic stimuli may influence different effector functions.
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Regulation of Experimental Autoimmune Encephalomyelitis by Natural Killer (NK) Cells
TL;DR: It is concluded that NK cells are an important regulator for EAE in both induction and effector phases, and it is shown thatNK cells inhibit T cell proliferation triggered by antigen or cytokine stimulation.
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The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells
TL;DR: It is demonstrated here that the NKT cell production of IFN-gamma is more susceptible to the sphingosine length of glycolipid ligand than that of IL-4 and that the length of the sphedosine chain determines the duration of N KT cell stimulation by CD1d-associated glycolIPids.
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Th2 bias of CD4+ NKT cells derived from multiple sclerosis in remission
Manabu Araki,Takayuki Kondo,Jenny E. Gumperz,Michael B. Brenner,Sachiko Miyake,Takashi Yamamura +5 more
TL;DR: It is reported that CD4(+) NKT line cells expanded from MS in remission (MS-rem) would produce a larger amount of IL-4 than those from HS or fromMS in relapse ( MS-rel), and the T(h)2 bias of CD4 (+) N KT line cells from MS-rem may support an immunoregulatory role for the CD4(--) NKT cells in vivo.
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Accumulation of Vα7.2–Jα33 invariant T cells in human autoimmune inflammatory lesions in the nervous system
TL;DR: The present results indicate that the Va7.2‐Ja33 T cells are involved in the autoimmune inflammatory lesions of multiple sclerosis and in the majority of the peripheral nerve samples from CIDP.