T
Takatsugu Hirokawa
Researcher at University of Tsukuba
Publications - 158
Citations - 6515
Takatsugu Hirokawa is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Chemistry & Docking (molecular). The author has an hindex of 27, co-authored 138 publications receiving 5674 citations. Previous affiliations of Takatsugu Hirokawa include National Institute of Advanced Industrial Science and Technology & Tokyo Medical and Dental University.
Papers
More filters
Journal ArticleDOI
SOSUI: classification and secondary structure prediction system for membrane proteins.
TL;DR: The system SOSUI for the discrimination of membrane proteins and soluble ones together with the prediction of transmembrane helices was developed, in which the accuracy of the classification of proteins was 99% and the corresponding value for the trans Membrane helix prediction was 97%.
Journal ArticleDOI
Ubiquitin is phosphorylated by PINK1 to activate parkin
Fumika Koyano,Kei Okatsu,Kei Okatsu,Hidetaka Kosako,Yasushi Tamura,Etsu Go,Mayumi Kimura,Yoko Kimura,Hikaru Tsuchiya,Hidehito Yoshihara,Takatsugu Hirokawa,Toshiya Endo,Edward A. Fon,Jean-François Trempe,Yasushi Saeki,Keiji Tanaka,Noriyuki Matsuda +16 more
TL;DR: The results show that PINK1-dependent phosphorylation of both parkin and ubiquitin is sufficient for full activation of parkin E3 activity, and demonstrate that phosphorylated ubiquit in is a parkin activator.
Journal ArticleDOI
Structural Basis for a Broad But Selective Ligand Spectrum of a Mouse Olfactory Receptor: Mapping the Odorant-Binding Site
TL;DR: The current study reveals the molecular environment of the odorant-binding site, and it further advances the understanding of GPCR pharmacology.
Journal ArticleDOI
Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands.
Kaname Kawajiri,Yasuhito Kobayashi,Fumiaki Ohtake,Togo Ikuta,Yoshibumi Matsushima,Junsei Mimura,Sven Pettersson,Richard S. Pollenz,Toshiyuki Sakaki,Takatsugu Hirokawa,Tetsu Akiyama,Masafumi Kurosumi,Lorenz Poellinger,Shigeaki Kato,Yoshiaki Fujii-Kuriyama +14 more
TL;DR: It is shown that the AhR E3 ubiquitin ligase has a role in suppression of intestinal carcinogenesis by a previously undescribed ligand-dependent β-catenin degradation pathway that is independent of and parallel to the APC system.
Journal ArticleDOI
Amphiphilicity index of polar amino acids as an aid in the characterization of amino acid preference at membrane–water interfaces
TL;DR: The moving average of the amphiphilicity index actually showed significant peaks in the end regions of most transmembrane helices, indicating their preference for the membrane-water interface.