T
Takayuki Hattori
Researcher at Hamamatsu University School of Medicine
Publications - 29
Citations - 2185
Takayuki Hattori is an academic researcher from Hamamatsu University School of Medicine. The author has contributed to research in topics: Ubiquitin ligase & Ubiquitin. The author has an hindex of 19, co-authored 29 publications receiving 2043 citations. Previous affiliations of Takayuki Hattori include Nagoya City University.
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Journal ArticleDOI
TRB3, a novel ER stress-inducible gene, is induced via ATF4–CHOP pathway and is involved in cell death
Nobumichi Ohoka,Satoshi Yoshii,Takayuki Hattori,Takayuki Hattori,Kikuo Onozaki,Hidetoshi Hayashi +5 more
TL;DR: The results indicate that TRB3 is a novel target of CHOP/ATF4 and downregulates its own induction by repression of CHop/atF4 functions, and that it is involved in CHOP‐dependent cell death during ER stress.
Journal ArticleDOI
Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation
Chiharu Uchida,Seiichi Miwa,Kyoko Kitagawa,Takayuki Hattori,Tomoyasu Isobe,Sunao Otani,Toshiaki Oda,Haruhiko Sugimura,Takehiko Kamijo,Keizou Ookawa,Hideyo Yasuda,Masatoshi Kitagawa +11 more
TL;DR: It is found that Mdm2, a ubiquitin ligase for p53, promoted ubiquitIn‐dependent degradation of pRB, and this results suggest that MDM2 regulates function of p RB via ubiquit in‐vivo and in vitro via Ubiquitin‐dependent degraded pRB.
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Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice
Hirotaka Fukasawa,Tatsuo Yamamoto,Akashi Togawa,Naro Ohashi,Yoshihide Fujigaki,Toshiaki Oda,Chiharu Uchida,Kyoko Kitagawa,Takayuki Hattori,Sayuri Suzuki,Masatoshi Kitagawa,Akira Hishida +11 more
TL;DR: The results suggest that the reduction of Smad7 protein resulting from enhanced ubiquitin-dependent degradation plays a pathogenic role in progression of tubulointerstitial fibrosis.
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Pirh2 Promotes Ubiquitin-Dependent Degradation of the Cyclin-Dependent Kinase Inhibitor p27Kip1
Takayuki Hattori,Tomoyasu Isobe,Kenji Abe,Hirotoshi Kikuchi,Kyoko Kitagawa,Toshiaki Oda,Chiharu Uchida,Masatoshi Kitagawa +7 more
TL;DR: Results indicate that Pirh2 acts as a negative regulator of p27(Kip1) function by promoting ubiquitin-dependent proteasomal degradation.
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Up-regulation of GPR48 Induced by Down-regulation of p27Kip1 Enhances Carcinoma Cell Invasiveness and Metastasis
Yun Gao,Kyoko Kitagawa,Yoshihiro Hiramatsu,Hirotoshi Kikuchi,Tomoyasu Isobe,Mai Shimada,Chiharu Uchida,Takayuki Hattori,Toshiaki Oda,Keiko Nakayama,Keiichi I. Nakayama,Tatsuo Tanaka,Hiroyuki Konno,Masatoshi Kitagawa +13 more
TL;DR: expression of the gene for G protein-coupled receptor 48 (GPR48) was significantly associated with lymph node metastasis and inversely correlated with p27 expression in human colon carcinomas, and may play an important role in invasiveness and metastasis of carcinoma.