T
Takuma Misawa
Researcher at University of Texas Southwestern Medical Center
Publications - 21
Citations - 1680
Takuma Misawa is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Inflammasome & Endoplasmic reticulum. The author has an hindex of 12, co-authored 19 publications receiving 1330 citations. Previous affiliations of Takuma Misawa include Osaka University.
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Journal ArticleDOI
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
Takuma Misawa,Michihiro Takahama,Tatsuya Kozaki,Hanna Lee,Jian Zou,Tatsuya Saitoh,Shizuo Akira +6 more
TL;DR: It is shown that microtubules mediated assembly of the NLRP3 inflammasome, and the creation of optimal sites for signal transduction by microtubule is required for activation of the entire NLRP2 inflammaome.
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Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1.
Tatsuya Saitoh,Jun Komano,Yasunori Saitoh,Takuma Misawa,Michihiro Takahama,Tatsuya Kozaki,Takuya Uehata,Hidenori Iwasaki,Hiroko Omori,Shoji Yamaoka,Naoki Yamamoto,Shizuo Akira +11 more
TL;DR: It is shown that NETs capture human immunodeficiency virus (HIV)-1 and promote HIV-1 elimination through myeloperoxidase and α-defensin and that NET formation is an antiviral response that is counteracted by HIV- 1.
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Resveratrol inhibits the acetylated α-tubulin-mediated assembly of the NLRP3-inflammasome.
TL;DR: It is shown that resveratrol, a natural polyphenol in grapes and wine, is a safe and effective phytochemical that inhibits NLRP3-inflammasome activation, and could be an effective medication for the treatment of NLRP2-related inflammatory diseases.
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Zinc-finger antiviral protein mediates retinoic acid inducible gene I–like receptor-independent antiviral response to murine leukemia virus
Hanna Lee,Jun Komano,Yasunori Saitoh,Shoji Yamaoka,Tatsuya Kozaki,Takuma Misawa,Michihiro Takahama,Takashi Satoh,Osamu Takeuchi,Naoki Yamamoto,Yoshiharu Matsuura,Tatsuya Saitoh,Shizuo Akira +12 more
TL;DR: It is definitively demonstrated that zinc-finger antiviral protein (ZAP) acts as a cytosolic RNA sensor, inducing the degradation of the MLV transcripts by the exosome, an RNA degradation system, on RNA granules.
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Macrophages control innate inflammation.
TL;DR: Trib1 is critical for adipose tissue maintenance and suppression of metabolic disorders by controlling the differentiation of tissue‐resident M2‐like macrophages.