T
Takuya Uehata
Researcher at Osaka University
Publications - 16
Citations - 1402
Takuya Uehata is an academic researcher from Osaka University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 9, co-authored 12 publications receiving 1169 citations.
Papers
More filters
Journal ArticleDOI
Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1.
Tatsuya Saitoh,Jun Komano,Yasunori Saitoh,Takuma Misawa,Michihiro Takahama,Tatsuya Kozaki,Takuya Uehata,Hidenori Iwasaki,Hiroko Omori,Shoji Yamaoka,Naoki Yamamoto,Shizuo Akira +11 more
TL;DR: It is shown that NETs capture human immunodeficiency virus (HIV)-1 and promote HIV-1 elimination through myeloperoxidase and α-defensin and that NET formation is an antiviral response that is counteracted by HIV- 1.
Journal ArticleDOI
Malt1-Induced Cleavage of Regnase-1 in CD4+ Helper T Cells Regulates Immune Activation
Takuya Uehata,Hidenori Iwasaki,Hidenori Iwasaki,Alexis Vandenbon,Kazufumi Matsushita,Eduardo Hernandez-Cuellar,Kanako Kuniyoshi,Takashi Satoh,Takashi Mino,Yutaka Suzuki,Daron M. Standley,Tohru Tsujimura,Hiromi Rakugi,Yoshitaka Isaka,Osamu Takeuchi,Osamu Takeuchi,Shizuo Akira +16 more
TL;DR: It is shown that Regnase-1 is essential for preventing aberrant effector CD4(+) T cell generation cell autonomously and Malt1 protease activity is critical for controlling the mRNA stability of T cell effector genes.
Journal ArticleDOI
The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR–IL-1R by controlling degradation of regnase-1
Hidenori Iwasaki,Osamu Takeuchi,Shunsuke Teraguchi,Kazufumi Matsushita,Kazufumi Matsushita,Takuya Uehata,Kanako Kuniyoshi,Takashi Satoh,Tatsuya Saitoh,Mutsuyoshi Matsushita,Daron M. Standley,Shizuo Akira +11 more
TL;DR: It is demonstrated that the IKK complex phosphorylates not only IκBα, thereby activating transcription, but also regnase-1, thereby releasing a 'brake' on IL-6 mRNA expression.
Journal ArticleDOI
Cigarette smoking and progression of IgA nephropathy.
Ryohei Yamamoto,Yasuyuki Nagasawa,Tatsuya Shoji,Hirotsugu Iwatani,Takayuki Hamano,Noritaka Kawada,Kazunori Inoue,Takuya Uehata,Tetsuya Kaneko,Noriyuki Okada,Toshiki Moriyama,Masaru Horio,Atsushi Yamauchi,Yoshiharu Tsubakihara,Enyu Imai,Hiromi Rakugi,Yoshitaka Isaka +16 more
TL;DR: Cigarette smoking, in a dose-dependent manner, was identified as a key prognostic factor in IgA nephropathy and smoking cessation should be encouraged as part of the treatment for IgA neutropathy.
Journal ArticleDOI
mRNA degradation by the endoribonuclease Regnase-1/ZC3H12a/MCPIP-1.
Takuya Uehata,Shizuo Akira +1 more
TL;DR: The mechanism of Regnase-1-mediated mRNA decay is discussed and the mechanism by which Regn enzyme-1 is tightly regulated in innate immune cells is described.