T
Takumi Abe
Researcher at Health Sciences University of Hokkaido
Publications - 91
Citations - 1187
Takumi Abe is an academic researcher from Health Sciences University of Hokkaido. The author has contributed to research in topics: Catalysis & Chemistry. The author has an hindex of 19, co-authored 81 publications receiving 993 citations. Previous affiliations of Takumi Abe include Hokkaido University & Health Science University.
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Catalytic Enantioselective Amination of Silyl Enol Ethers Using Chiral Dirhodium(II) Carboxylates: Asymmetric Formal Synthesis of (−)-Metazocine†
TL;DR: The effectiveness of the present catalytic protocol has been demonstrated by an asymmetric formal synthesis of (-)-metazocine, providing N-(2-nitrophenylsulfonyl)-alpha-amino ketones in high yields and with enantioselectivities of up to 95% ee.
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Revisiting AI-2 quorum sensing inhibitors: direct comparison of alkyl-DPD analogues and a natural product fimbrolide.
Colin A. Lowery,Takumi Abe,Junguk Park,Lisa M. Eubanks,Daisuke Sawada,Gunnar F. Kaufmann,Kim D. Janda +6 more
TL;DR: It is demonstrated that the alkyl-DPD analogues are more potent inhibitors of QS in both Vibrio harveyi and Salmonella typhimurium, the two organisms with defined AI-2 QS systems, and in doing so call into question the widely accepted use of fimbrolide-derived compounds as the "gold standard" ofAI-2 inhibition.
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One-pot construction of 3,3'-bisindolylmethanes through Bartoli indole synthesis.
TL;DR: A one-pot approach to 3,3'-bisindolylmethane derivatives from nitrobenzene derivatives through the Bartoli indole synthesis was developed, in which the acid used to quench the reaction markedly affected its outcome.
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Concise total synthesis of calothrixins A and B.
TL;DR: The concise total synthesis of calothrixins A and B has been accomplished by utilizing the one-pot formation of hexatriene as a key intermediate via the palladium-catalyzed tandem cyclization/cross-coupling reaction of triethyl(indol-2-yl)borate.
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A copper-catalyzed Ritter-type cascade via iminoketene for the synthesis of quinazolin-4(3H)-ones and diazocines
TL;DR: A copper-catalyzed Ritter-type reaction/cyclization cascade of anthranilic acids and nitriles, affording the quinazolin-4(3H)-ones in one-pot, and a novel Ritters' type reaction/condensation/intramolecular anti-Markovnikov hydroamination cascade, providing access to functionalized diazocines inOne-pot.