T
Tamar Jana
Researcher at Weizmann Institute of Science
Publications - 7
Citations - 293
Tamar Jana is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Transcription factor & Biology. The author has an hindex of 3, co-authored 4 publications receiving 93 citations.
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Journal ArticleDOI
Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity
Sagie Brodsky,Tamar Jana,Karin Mittelman,Michal Chapal,Divya Krishna Kumar,Miri Carmi,Naama Barkai +6 more
TL;DR: It is proposed that distribution of sensing determinants along extended IDRs accelerates binding-site detection by rapidly localizing TFs to broad DNA regions surrounding these sites.
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A single cell atlas of the human liver tumor microenvironment.
Hassan Massalha,Keren Bahar Halpern,Samir Abu-Gazala,Samir Abu-Gazala,Tamar Jana,Efi E. Massasa,Andreas E. Moor,Lisa Buchauer,Milena Rozenberg,Eli Pikarsky,Ido Amit,Gideon Zamir,Shalev Itzkovitz +12 more
TL;DR: It is found that stromal cells exhibit recurring, patient‐independent expression programs, and a ligand–receptor map that highlights recurring tumor–stroma interactions is reconstructed that provides a resource for understanding human liver malignancies.
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Speed–Specificity Trade-Offs in the Transcription Factors Search for Their Genomic Binding Sites
TL;DR: In this paper, the authors discuss potential speed-specificity trade-offs in the context of existing models and further discuss the recently described "distributed specificity" paradigm, suggesting that intrinsically disordered regions (IDRs) promote specificity while reducing the TF-target search time.
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Order through disorder: The role of intrinsically disordered regions in transcription factor binding specificity
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Complementary strategies for directing in vivo transcription factor binding through DNA binding domains and intrinsically disordered regions.
TL;DR: In this article , the relative roles of DBDs and non-DBDs in directing binding preferences of budding yeast transcription factors were investigated. But the results of the experiments were limited to the case of a few mutants.