T
Tamara Tilburgs
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 45
Citations - 2989
Tamara Tilburgs is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 24, co-authored 38 publications receiving 2247 citations. Previous affiliations of Tamara Tilburgs include Leiden University Medical Center & University of Cincinnati Academic Health Center.
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Journal ArticleDOI
Evidence for a selective migration of fetus-specific CD4+CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy.
Tamara Tilburgs,Dave L. Roelen,Barbara J. van der Mast,Godelieve M. de Groot-Swings,Carin Kleijburg,S.A. Scherjon,Frans H. J. Claas +6 more
TL;DR: Examination of phenotypic and functional properties of CD4+CD25bright T cells derived from maternal peripheral blood and decidual tissue suggest a preferential recruitment of fetus-specific regulatory T cells from mothers' peripheral blood to the fetal-maternal interface, where they may contribute to the local regulation ofetus-specific responses.
Journal ArticleDOI
Two Unique Human Decidual Macrophage Populations
TL;DR: Two distinct subsets of CD14+ decidual macrophages (dMɸs) are found to be present in first-trimester decidua, and each secrete both proinflammatory and anti-inflammatory cytokines that may contribute to the balance that establishes fetal–maternal tolerance.
Journal ArticleDOI
Differential Distribution of CD4+CD25bright and CD8+CD28− T-cells in Decidua and Maternal Blood During Human Pregnancy
Tamara Tilburgs,Dave L. Roelen,B.J. van der Mast,J.J. van Schip,Carin Kleijburg,G.M. de Groot-Swings,Humphrey H.H. Kanhai,Frans H.J. Claas,Sicco A. Scherjon +8 more
TL;DR: The aim of this study was to determine the distribution of specific T-cell subsets in d.
Journal ArticleDOI
Fetal-maternal HLA-C mismatch is associated with decidual T cell activation and induction of functional T regulatory cells.
Tamara Tilburgs,Sicco A. Scherjon,Barbara J. van der Mast,Geert W. Haasnoot,Minke Versteeg-v.d.Voort-Maarschalk,Dave L. Roelen,Johannes J. van Rood,Frans H.J. Claas +7 more
TL;DR: It is shown that pregnancies containing a HLA-C mismatched child induce an increased percentage of CD4(+)CD25(dim) activated T cells in decidual tissue, which suggests thatDecidual T cells specifically recognize fetal HLA -C at the fetal-maternal interface but are prevented from inducing a destructive immune response in uncomplicated pregnancies.
Journal ArticleDOI
HLA-G: At the Interface of Maternal–Fetal Tolerance
TL;DR: New insights into the mechanisms controlling the expression and function of HLA-G at the maternal-fetal interface are critically reviewed, and their relevance for fetal tolerance is discussed.