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Barbara J. van der Mast
Researcher at Leiden University Medical Center
Publications - 22
Citations - 1347
Barbara J. van der Mast is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Transplantation & IL-2 receptor. The author has an hindex of 14, co-authored 22 publications receiving 1247 citations. Previous affiliations of Barbara J. van der Mast include Erasmus University Medical Center & Leiden University.
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Journal ArticleDOI
Evidence for a selective migration of fetus-specific CD4+CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy.
Tamara Tilburgs,Dave L. Roelen,Barbara J. van der Mast,Godelieve M. de Groot-Swings,Carin Kleijburg,S.A. Scherjon,Frans H. J. Claas +6 more
TL;DR: Examination of phenotypic and functional properties of CD4+CD25bright T cells derived from maternal peripheral blood and decidual tissue suggest a preferential recruitment of fetus-specific regulatory T cells from mothers' peripheral blood to the fetal-maternal interface, where they may contribute to the local regulation ofetus-specific responses.
Journal ArticleDOI
Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cells
Carla C. Baan,Barbara J. van der Mast,Mariska Klepper,W. M. Mol,Annemiek M.A. Peeters,Sander S. Korevaar,Aggie H.M.M. Balk,Willem Weimar +7 more
TL;DR: The high FOXP3 mRNA levels during allogeneic responses in vivo and in vitro suggests that regulatory activities of CD25 bright+ T cells or the generation of these cells is an intrinsic part of activation.
Journal ArticleDOI
Fetal-maternal HLA-C mismatch is associated with decidual T cell activation and induction of functional T regulatory cells.
Tamara Tilburgs,Sicco A. Scherjon,Barbara J. van der Mast,Geert W. Haasnoot,Minke Versteeg-v.d.Voort-Maarschalk,Dave L. Roelen,Johannes J. van Rood,Frans H.J. Claas +7 more
TL;DR: It is shown that pregnancies containing a HLA-C mismatched child induce an increased percentage of CD4(+)CD25(dim) activated T cells in decidual tissue, which suggests thatDecidual T cells specifically recognize fetal HLA -C at the fetal-maternal interface but are prevented from inducing a destructive immune response in uncomplicated pregnancies.
Journal ArticleDOI
Human Decidual Tissue Contains Differentiated CD8(+) Effector-Memory T Cells with Unique Properties
Tamara Tilburgs,Dorrith Schonkeren,Michael Eikmans,Nicole M.A. Nagtzaam,Gert Datema,Godelieve M.J.S. Swings,Frans A. Prins,Jan M. M. van Lith,Barbara J. van der Mast,Dave L. Roelen,Sicco A. Scherjon,Frans H.J. Claas +11 more
TL;DR: Examination of the decidual and peripheral CD8+ T cell pool for CD45RA, CCR7, CD28, and CD27 expression shows a significantly reduced expression of perforin and granzyme B, which was confirmed by immunohistochemistry of decidUAL tissue sections.
Journal ArticleDOI
Differential immunomodulatory effects of fetal versus maternal multipotent stromal cells
Dave L. Roelen,Barbara J. van der Mast,Pieternella S. in `t Anker,Carin Kleijburg,Michael Eikmans,Els van Beelen,Godelieve M.J.S. de Groot-Swings,W. E. Fibbe,Humphrey H.H. Kanhai,Sicco A. Scherjon,Frans H.J. Claas +10 more
TL;DR: Fetal MSC derived from the fetomaternal interface have a stronger inhibitory effect on naive and antigen-experienced T cells compared with maternal MSC, which is probably related to their higher IL-10 production.