T
Tammy L. Sirich
Researcher at Stanford University
Publications - 46
Citations - 1723
Tammy L. Sirich is an academic researcher from Stanford University. The author has contributed to research in topics: Hemodialysis & Medicine. The author has an hindex of 18, co-authored 40 publications receiving 1267 citations. Previous affiliations of Tammy L. Sirich include Veterans Health Administration & VA Palo Alto Healthcare System.
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Journal ArticleDOI
Effect of Increasing Dietary Fiber on Plasma Levels of Colon-Derived Solutes in Hemodialysis Patients
Tammy L. Sirich,Natalie S. Plummer,Christopher D. Gardner,Thomas H. Hostetter,Timothy W. Meyer +4 more
TL;DR: Increasing dietary fiber in hemodialysis patients may reduce the plasma levels of the colon-derived solutes indoxyl sulfate and possibly p-cresol sulfate without the need to intensify dialysis treatments.
Journal ArticleDOI
Uremic solutes and risk of end-stage renal disease in type 2 diabetes: metabolomic study.
Monika A. Niewczas,Monika A. Niewczas,Tammy L. Sirich,Anna V. Mathew,Jan Skupien,Jan Skupien,Jan Skupien,Robert P. Mohney,James H. Warram,James H. Warram,Adam M. Smiles,Xiaoping Huang,Walker Walker,Jaeman Byun,Edward D. Karoly,Elizabeth Kensicki,Gerard T. Berry,Gerard T. Berry,Joseph V. Bonventre,Joseph V. Bonventre,Subramaniam Pennathur,Timothy W. Meyer,Andrzej S. Krolewski,Andrzej S. Krolewski +23 more
TL;DR: Normal plasma concentrations of putative uremic solutes and essential amino acids either contribute to progression to ESRD or are a manifestation of an early stage(s) of the disease process that leads to E SRD in T2D.
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Indoxyl Sulfate-Review of Toxicity and Therapeutic Strategies.
Sheldon C. Leong,Tammy L. Sirich +1 more
TL;DR: Toxicity data, albeit inconclusive, have prompted efforts to lower the plasma levels of indoxyl sulfate through dialytic and non-dialytic means and no trials have yet tested cardiovascular or mortality benefit.
Journal ArticleDOI
Numerous protein-bound solutes are cleared by the kidney with high efficiency
TL;DR: Analysis of solutes efficiently cleared by secretion in the native kidney may provide a potential route to the identification of uremic toxins.
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Prominent Accumulation in Hemodialysis Patients of Solutes Normally Cleared by Tubular Secretion
TL;DR: Molecular modeling showed that prominent accumulation of the normally secreted solutes in hemodialysis patients could be accounted for by lower dialytic clearance relative to physiologic clearance combined with the intermittency of treatment.