Joseph V. Bonventre

TL;DR: Modest changes in SCr were significantly associated with mortality, LOS, and costs, even after adjustment for age, gender, admission International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis, severity of illness (diagnosis-related group weight), and chronic kidney disease.

TL;DR: A soluble form of human KIM-1 can be detected in the urine of patients with ATN and may serve as a useful biomarker for renal proximal tubule injury facilitating the early diagnosis of the disease and serving as a diagnostic discriminator.

TL;DR: The major components of this dynamic process, which involves hemodynamic alterations, inflammation, and endothelial and epithelial cell injury, followed by repair that can be adaptive and restore epithelial integrity or maladaptive, leading to chronic kidney disease are reviewed.

TL;DR: Data indicate that therapeutic strategies directly targeting pericyte differentiation in vivo may productively impact fibrotic kidney disease.

TL;DR: Prostaglandin E2 levels in the cerebrospinal fluid are Elevated by finding a widespread induction of Cox-2 expression in spinal cord neurons and in other regions of the CNS, and preventing central prostanoid production by inhibiting the interleukin-1β-mediated induction ofcox-2 in neurons reduces centrally generated inflammatory pain hypersensitivity.