Tanja K. Rudolph

TL;DR: Results show that the oleic acid nitroalkene derivative OA-NO2 attenuates hypoxia-induced pulmonary hypertension in mice, which represents a potential therapeutic agent for the treatment of PAH.

TL;DR: The current data underscore the role of MPO as diagnostic marker in acute coronary disease; however the additive information derived from MPO is restricted to patients presenting in the early phase of symptom onset.

TL;DR: Elevation of circulating MPO was irrespective of the etiology of heart failure and independent of traditional confounding variables, and systemic leukocyte activation with increased transcription of MPO mRNA and augmented release ofMPO appears to represent a so far underrecognized characteristic in LV dysfunction, which was revealed to be irrespective ofThe underlying pathology.

TL;DR: Central mechanisms by which these enzymes can modulate the structural and functional integrity of the vessel wall have been characterized and increased the understanding of neutrophil-derived changes in vascular homeostasis in response to smoking and nicotine, respectively.

TL;DR: In this paper, the role of Menkes ATPase (MNK) in the regulation of extracellular superoxide dismutase (SOD3) activity and hypertension in mice was investigated.