Tanja Mletzko

TL;DR: Results from a series of clinical studies suggesting that childhood trauma in humans is associated with sensitization of the neuroendocrine stress response, glucocorticoid resistance, increased central corticotropin-releasing factor activity, immune activation, and reduced hippocampal volume are summarized, indicating the existence of biologically distinguishable subtypes of depression as a function of childhood trauma.

TL;DR: Trier Social Stress Test-induced increases in IL-6 and NF-κB DNA-binding were greater in major depression patients with increased early life stress and independently correlated with depression severity, but not early life Stress.

TL;DR: In this paper, the authors determined the impact of childhood trauma on dexamethasone/corticotropin-releasing factor (CRF) test results in patients with major depression.

TL;DR: The results suggest that the CRHR1 gene may only moderate the effects of specific types of childhood trauma on depression, and gender differences in environmental exposures could be reflected in sex-specific CRHR 1 × child abuse interactions.

TL;DR: The childhood maltreatment‐related reorganization of a brain inhibitory control network provides sex‐dependent mechanisms by which childhood adversity may confer greater risk for drug use and related disorders and by which adaptive brain responses protect individuals from this risk factor.