T
Tara A. Gianoulis
Researcher at Harvard University
Publications - 9
Citations - 1102
Tara A. Gianoulis is an academic researcher from Harvard University. The author has contributed to research in topics: Ontology (information science) & Ascocoryne sarcoides. The author has an hindex of 7, co-authored 9 publications receiving 1011 citations. Previous affiliations of Tara A. Gianoulis include Wyss Institute for Biologically Inspired Engineering & Yale University.
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Journal ArticleDOI
Precise manipulation of chromosomes in vivo enables genome-wide codon replacement.
Farren J. Isaacs,Peter A. Carr,Harris H. Wang,Marc J. Lajoie,Bram Sterling,Laurens Kraal,Andrew C. Tolonen,Tara A. Gianoulis,Daniel B. Goodman,Daniel B. Goodman,Nikos Reppas,Christopher J. Emig,Duhee Bang,Samuel J. Hwang,Michael C. Jewett,Michael C. Jewett,Joseph M. Jacobson,George M. Church +17 more
TL;DR: H hierarchical conjugative assembly genome engineering (CAGE) was developed to merge these sets of codon modifications into genomes with 80 precise changes, which demonstrate that these synonymous codon substitutions can be combined into higher-order strains without synthetic lethal effects.
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Diverse Roles and Interactions of the SWI/SNF Chromatin Remodeling Complex Revealed Using Global Approaches
Ghia Euskirchen,Raymond K. Auerbach,Eugene Davidov,Tara A. Gianoulis,Guoneng Zhong,Joel Rozowsky,Nitin Bhardwaj,Mark Gerstein,Michael Snyder +8 more
TL;DR: The results from the ChIP and immunoprecipitation experiments suggest that SWI/SNF facilitates gene regulation and genome function more broadly and through a greater diversity of interactions than previously appreciated.
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Genomic analysis of the hydrocarbon-producing, cellulolytic, endophytic fungus Ascocoryne sarcoides.
Tara A. Gianoulis,Tara A. Gianoulis,Tara A. Gianoulis,Meghan A. Griffin,Daniel Spakowicz,Brian F. Dunican,Cambria J. Alpha,Andrea Sboner,A. Michael Sismour,A. Michael Sismour,Chinnappa D. Kodira,Michael Egholm,George M. Church,George M. Church,Mark Gerstein,Scott A. Strobel +15 more
TL;DR: This is one of the highest quality fungal genomes and, to the authors' knowledge, the only thoroughly annotated and transcriptionally profiled fungal endophyte genome currently available and provides the genomic foundation for the study of a model endophytes system.
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Regulatory Variation Within and Between Species
TL;DR: In this article, a review of differential gene regulation focusing on evolutionary-developmental biology, global comparison of genomic sequences, whole-genome gene expression, and transcription factor (TF) binding profiles is presented.
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Volatile organic compound production by organisms in the genus Ascocoryne and a re-evaluation of myco-diesel production by NRRL 50072
TL;DR: Comparison of NRRL 50072 and Ascocoryne strains could facilitate future studies to identify and manipulate the biosynthetic machinery responsible for production of individual VOCs, including several that have a potential application as biofuels.