A
Andrew C. Tolonen
Researcher at Université Paris-Saclay
Publications - 34
Citations - 4162
Andrew C. Tolonen is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Clostridium phytofermentans & Genome. The author has an hindex of 19, co-authored 31 publications receiving 3704 citations. Previous affiliations of Andrew C. Tolonen include Woods Hole Oceanographic Institution & Broad Institute.
Papers
More filters
Journal ArticleDOI
Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation
Gabrielle Rocap,Frank W. Larimer,Frank W. Larimer,Jane Lamerdin,Stephanie Malfatti,Patrick S. G. Chain,Patrick S. G. Chain,Nathan A. Ahlgren,Andrae Arellano,Maureen L. Coleman,Loren Hauser,Loren Hauser,Wolfgang R. Hess,Zackary I. Johnson,Miriam Land,Miriam Land,Debbie Lindell,Anton F. Post,Warren Regala,Manesh Shah,Manesh Shah,Stephanie L. Shaw,Claudia Steglich,Matthew B. Sullivan,Claire S. Ting,Andrew C. Tolonen,Eric A. Webb,Erik R. Zinser,Sallie W. Chisholm +28 more
TL;DR: The genomes of two Prochlorococcus strains that span the largest evolutionary distance within the Pro chlorococcus lineage are compared and reveal dynamic genomes that are constantly changing in response to myriad selection pressures.
Journal ArticleDOI
DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
Siu Sylvia Lee,Scott Kennedy,Scott Kennedy,Andrew C. Tolonen,Andrew C. Tolonen,Gary Ruvkun,Gary Ruvkun +6 more
TL;DR: Genetic analysis of 17 orthologous genes from Caenorhabditis and Drosophila showed that many of these genes mediate distinct aspects of daf-16 function, including longevity, metabolism, and development.
Journal ArticleDOI
Precise manipulation of chromosomes in vivo enables genome-wide codon replacement.
Farren J. Isaacs,Peter A. Carr,Harris H. Wang,Marc J. Lajoie,Bram Sterling,Laurens Kraal,Andrew C. Tolonen,Tara A. Gianoulis,Daniel B. Goodman,Daniel B. Goodman,Nikos Reppas,Christopher J. Emig,Duhee Bang,Samuel J. Hwang,Michael C. Jewett,Michael C. Jewett,Joseph M. Jacobson,George M. Church +17 more
TL;DR: H hierarchical conjugative assembly genome engineering (CAGE) was developed to merge these sets of codon modifications into genomes with 80 precise changes, which demonstrate that these synonymous codon substitutions can be combined into higher-order strains without synthetic lethal effects.
Journal ArticleDOI
Transfer of photosynthesis genes to and from Prochlorococcus viruses
Debbie Lindell,Matthew B. Sullivan,Zackary I. Johnson,Andrew C. Tolonen,Forest Rohwer,Sallie W. Chisholm +5 more
TL;DR: The presence of genes central to oxygenic photosynthesis in the genomes of three phages from two viral families that infect the marine cyanobacterium Prochlorococcus is reported, indicating that they are of cyanobacterial origin.
Journal ArticleDOI
Human genetic variation and the gut microbiome in disease.
TL;DR: A number of recent findings support the hypothesis that certain host genetic variants predispose an individual towards microbiome dysbiosis, a condition in which the normal microbiome population structure is disturbed.