T
Tarangini Deshpande
Publications - 4
Citations - 670
Tarangini Deshpande is an academic researcher. The author has contributed to research in topics: Drug repositioning & Gene. The author has an hindex of 4, co-authored 4 publications receiving 589 citations.
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Exploiting drug–disease relationships for computational drug repositioning
TL;DR: In this review, it is shown that computational methods for drug repositioning can be classified in two axes: drug based, where discovery initiates from the chemical perspective, or disease based,where discovery begins from the clinical perspective of disease or its pathology.
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Disease signatures are robust across tissues and experiments
Joel T. Dudley,Joel T. Dudley,Robert Tibshirani,Tarangini Deshpande,Atul J. Butte,Atul J. Butte +5 more
TL;DR: A large‐scale analysis of disease‐associated experiments obtained from NCBI GEO finds evidence for a general, pathophysiological concordance between experiments measuring the same disease condition, and that the molecular signature of disease across tissues is overall more prominent than the signature of tissue expression across diseases.
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FitSNPs: highly differentially expressed genes are more likely to have variants associated with disease.
Rong-Rong Chen,Rong-Rong Chen,Alexander A. Morgan,Alexander A. Morgan,Joel T. Dudley,Joel T. Dudley,Tarangini Deshpande,Li Li,Keiichi Kodama,Keiichi Kodama,Annie P. Chiang,Annie P. Chiang,Atul J. Butte,Atul J. Butte +13 more
TL;DR: This study demonstrates that highly differentially expressed genes are more likely to harbor disease-associated DNA variants and FitSNPs can serve as an effective tool to systematically prioritize candidate SNPs from GWASs.
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Dynamism in gene expression across multiple studies
TL;DR: Methods of examining gene expression dynamics, how and when genes change expression, are developed and demonstrated in a meta-analysis involving over 29,000 microarrays and have a new way of characterizing dynamics, complementary to measures looking at changes in absolute variation or breadth of tissues showing expression.