T
Tarek G. Gharib
Researcher at University of Michigan
Publications - 16
Citations - 4076
Tarek G. Gharib is an academic researcher from University of Michigan. The author has contributed to research in topics: Adenocarcinoma & Computer science. The author has an hindex of 10, co-authored 10 publications receiving 3929 citations.
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Journal ArticleDOI
Gene-expression profiles predict survival of patients with lung adenocarcinoma
David G. Beer,Sharon L.R. Kardia,Chiang Ching Huang,Thomas J. Giordano,Albert M. Levin,David E. Misek,Lin Lin,Guoan Chen,Tarek G. Gharib,Dafydd G. Thomas,Michelle L. Lizyness,Rork Kuick,Satoru Hayasaka,Jeremy M. G. Taylor,Mark D. Iannettoni,Mark B. Orringer,Samir M. Hanash +16 more
TL;DR: The identification of a set of genes that predict survival in early-stage lung adenocarcinoma allows delineation of a high-risk group that may benefit from adjuvant therapy.
Journal ArticleDOI
Discordant Protein and mRNA Expression in Lung Adenocarcinomas
Guoan Chen,Tarek G. Gharib,Chiang Ching Huang,Jeremy M. G. Taylor,David E. Misek,Sharon L.R. Kardia,Thomas J. Giordano,Mark D. Iannettoni,Mark B. Orringer,Samir M. Hanash,David G. Beer +10 more
TL;DR: The relationship between gene expression measured at the mRNA level and the corresponding protein level is not well characterized in human cancer, and it is shown that only a subset of the proteins exhibited a significant correlation with mRNA abundance.
Journal Article
Proteomic Analysis of Lung Adenocarcinoma: Identification of a Highly Expressed Set of Proteins in Tumors
Guoan Chen,Tarek G. Gharib,Chiang Ching Huang,Dafydd G. Thomas,Kerby Shedden,Jeremy M. G. Taylor,Sharon L.R. Kardia,David E. Misek,Thomas J. Giordano,Mark D. Iannettoni,Mark B. Orringer,Samir M. Hanash,David G. Beer +12 more
TL;DR: Two-dimensional PAGE and mass spectrometry can identify proteins showing increased expression in lung adenocarcinoma and the association of specific isoforms of these proteins with clinical variables and understanding the regulation of their expression will aid in determined their potential use as biomarkers in this cancer.
Journal ArticleDOI
Protein profiles associated with survival in lung adenocarcinoma
Guoan Chen,Tarek G. Gharib,Hong Wang,Chiang Ching Huang,Rork Kuick,Dafydd G. Thomas,Kerby Shedden,David E. Misek,Jeremy M. G. Taylor,Thomas J. Giordano,Sharon L.R. Kardia,Mark D. Iannettoni,John Yee,Philip J. Hogg,Mark B. Orringer,Samir M. Hanash,David G. Beer +16 more
TL;DR: These studies identify new prognostic biomarkers and indicate that protein expression profiles can predict the outcome of patients with early-stage lung cancer.
Journal ArticleDOI
Reduced selenium-binding protein 1 expression is associated with poor outcome in lung adenocarcinomas
Guoan Chen,Hong Wang,Charles T. Miller,Dafydd G. Thomas,Tarek G. Gharib,David E. Misek,Thomas J. Giordano,Mark B. Orringer,Samir M. Hanash,David G. Beer +9 more
TL;DR: Analysis of the tumour proliferation status using Ki‐67 suggests that down‐regulated expression of SBP1 may reflect increased cell proliferation and decreased differentiation in lung adenocarcinomas.