The saimie paper suggests how susceptible individuals could reduce their total intake of aluminium. In presenting the cpidemiological evidence for a link betveen aluminium and Alzheimcr's, Nart'n suggests that although definite proof is still lacking, there is more than enough positixe evidence to fuel further epidemiological investigation. It states that such investigations might specificallx address the issue of the confounding cffect of silicon and an assessment of exposure to spccific

https://jech.bmj.com/content/jech/47/6/511.4.full.pdf

Methodology for Genetic Studies of Twins and Families

The Analysis of Variance.

I describe a Bayesian method to account for measurement errors in linear regression of astronomical data. The method allows for heteroscedastic and possibly correlated measurement errors and intrinsic scatter in the regression relationship. The method is based on deriving a likelihood function for the measured data, and I focus on the case when the intrinsic distribution of the independent variables can be approximated using a mixture of Gaussian functions. I generalize the method to incorporate multiple independent variables, nondetections, and selection effects (e.g., Malmquist bias). A Gibbs sampler is described for simulating random draws from the probability distribution of the parameters, given the observed data. I use simulation to compare the method with other common estimators. The simulations illustrate that the Gaussian mixture model outperforms other common estimators and can effectively give constraints on the regression parameters, even when the measurement errors dominate the observed scatter, source detection fraction is low, or the intrinsic distribution of the independent variables is not a mixture of Gaussian functions. I conclude by using this method to fit the X-ray spectral slope as a function of Eddington ratio using a sample of 39 z 0.8 radio-quiet quasars. I confirm the correlation seen by other authors between the radio-quiet quasar X-ray spectral slope and the Eddington ratio, where the X-ray spectral slope softens as the Eddington ratio increases. IDL routines are made available for performing the regression.

https://iopscience.iop.org/article/10.1086/519947/pdf

Some Aspects of Measurement Error in Linear Regression of Astronomical Data

THE best adjective to describe this work is \"sweep11 ing.\" The range of subject matter is so broad that it can almost be described as containing everything except fuzzy set theory. Included are explicit discussions of the basics of probability (relegated to an appendix); the practice of problem solving; testing hypotheses about statistical parameters; calculating and interpreting confidence limits; tolerance limits and prediction limits; setting up and interpreting control charts; design of experiments; analysis of variance; line and surface fitting; and maximum likelihood procedures. If you can think of something that is not in this list, then it probably means I have overlooked it.

Experiments: Planning, Analysis, and Parameter Design Optimization

Bisulfite sequencing (BS-seq) is the gold standard for studying genome-wide DNA methylation. We developed MOABS to increase the speed, accuracy, statistical power and biological relevance of BS-seq data analysis. MOABS detects differential methylation with 10-fold coverage at single-CpG resolution based on a Beta-Binomial hierarchical model and is capable of processing two billion reads in 24 CPU hours. Here, using simulated and real BS-seq data, we demonstrate that MOABS outperforms other leading algorithms, such as Fisher’s exact test and BSmooth. Furthermore, MOABS analysis can be easily extended to differential 5hmC analysis using RRBS and oxBS-seq. MOABS is available at http://code.google.com/p/moabs/.

/pdf/moabs-model-based-analysis-of-bisulfite-sequencing-data-398hoqmwjc.pdf

MOABS: model based analysis of bisulfite sequencing data

Suppose that a finite population consists of N distinct units. Associated with the ith unit is a polychotomous response vector, d
 i
 , and a vector of auxiliary variable x
 i
 . The values x
 i
 ’s are known for the entire population but d
 i
 ’s are known only for the units selected in the sample. The problem is to estimate the finite population proportion vector P. One of the fundamental questions in finite population sampling is how to make use of the complete auxiliary information effectively at the estimation stage. In this article a predictive estimator is proposed which incorporates the auxiliary information at the estimation stage by invoking a superpopulation model. However, the use of such estimators is often criticized since the working superpopulation model may not be correct. To protect the predictive estimator from the possible model failure, a nonparametric regression model is considered in the superpopulation. The asymptotic properties of the proposed estimator are derived and also a bootstrap-based hybrid re-sampling method for estimating the variance of the proposed estimator is developed. Results of a simulation study are reported on the performances of the predictive estimator and its re-sampling-based variance estimator from the model-based viewpoint. Finally, a data survey related to the opinions of 686 individuals on the cause of addiction is used for an empirical study to investigate the performance of the nonparametric predictive estimator from the design-based viewpoint.

Inference on finite population categorical response: nonparametric regression-based predictive approach

In practical data analysis, often an important problem is to determine the number of clumps in discrete data in the form of proportions. This can be done through model selection in a multi-clump finite mixture model. In this paper, we propose bootstrap likelihood ratio tests to test the fit of a multinomial model against the single clump finite mixture distribution and to determine the number of clumps in the data, that is, to select a model with appropriate number of clumps. Shortcomings of some traditional large sample procedures are also shown. Three datasets are analyzed. Copyright © 2009 John Wiley & Sons, Ltd.

The multi‐clump finite mixture distribution and model selection

This paper considers regression models for mixed binary and continuous outcomes, when the true predictor is measured with error and the binary responses are subject to classification errors The focus of the paper is to study the effects of these errors on the estimates of the model parameters and also to propose a model that incorporates both these errors The proposed model results in a substantial improvement in the estimates as shown by extensive simulation studies

/pdf/analysis-of-mixed-outcomes-misclassified-binary-responses-nqlxr53kqw.pdf

Analysis of mixed outcomes: misclassified binary responses and measurement error in covariates

Two-way nested design with mixed effects model arises in many practical situations. In the classical analysis of variance set-up, a test for the absence of the random effects is obtained under the assumption that the random effects and the errors are normally distributed. The present paper avoids this assumption and provides an asymptotically distribution-free test procedure for the above problem. The asymptotic null distribution of the test statistic is obtained. Actual implementation of the test is straight forward given the prior information on quantiles of the intra-block differences of observations. In the absence of such information, working test procedures are proposed. The performances of these tests are compared with the classical analysis of variance test through simulations. The tests are then illustrated by some real data sets.

/pdf/testing-for-the-absence-of-random-effects-in-a-two-way-4x9s87wtm4.pdf

Testing for the Absence of Random Effects in a Two-way Nested Design with Mixed Effects Model: A Nonparametric Approach

Shoutir Kishore Chatterjee was born in Ranchi, a small hill station in India, on November 6, 1934. He received his B.Sc. in statistics from the Presidency College, Calcutta, in 1954, and M.Sc. and Ph.D. degrees in statistics from the University of Calcutta in 1956 and 1962, respectively. He was appointed a lecturer in the Department of Statistics, University of Calcutta, in 1960 and was a member of its faculty until his retirement as a professor in 1997. Indeed, from the 1970s he steered the teaching and research activities of the department for the next three decades. Professor Chatterjee was the National Lecturer in Statistics (1985–1986) of the University Grants Commission, India, the President of the Section of Statistics of the Indian Science Congress (1989) and an Emeritus Scientist (1997–2000) of the Council of Scientific and Industrial Research, India. Professor Chatterjee, affectionately known as SKC to his students and admirers, is a truly exceptional person who embodies the spirit of eternal India. He firmly believes that “fulfillment in man’s life does not come from amassing a lot of money, after the threshold of what is required for achieving a decent living is crossed. It does not come even from peer recognition for intellectual achievements. Of course, one has to work and toil a lot before one realizes these facts.”

/pdf/a-conversation-with-shoutir-kishore-chatterjee-28lqm9pri1.pdf

Tathagata Banerjee

Papers

Inference on finite population categorical response: nonparametric regression-based predictive approach

The multi‐clump finite mixture distribution and model selection

Analysis of mixed outcomes: misclassified binary responses and measurement error in covariates

Testing for the Absence of Random Effects in a Two-way Nested Design with Mixed Effects Model: A Nonparametric Approach

A Conversation with Shoutir Kishore Chatterjee