T
Tatyana A. Voyno-Yasenetskaya
Researcher at University of Illinois at Chicago
Publications - 53
Citations - 3776
Tatyana A. Voyno-Yasenetskaya is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Heterotrimeric G protein & G protein. The author has an hindex of 31, co-authored 53 publications receiving 3581 citations.
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Journal ArticleDOI
Lipopolysaccharide Stimulates Platelet Secretion and Potentiates Platelet Aggregation via TLR4/MyD88 and the cGMP-Dependent Protein Kinase Pathway
Guoying Zhang,Jingyan Han,Emily J. Welch,Richard D. Ye,Tatyana A. Voyno-Yasenetskaya,Asrar B. Malik,Xiaoping Du,Zhenyu Li +7 more
TL;DR: It is shown that LPS stimulates platelet secretion of dense and α granules as indicated by ATP release and P-selectin expression, and thus enhances platelet activation induced by low concentrations of platelet agonists, and potentiates platelet aggregation through a TLR4/MyD88- and cGMP/PKG-dependent pathway.
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Differential Expression of Adenosine Receptors in Human Endothelial Cells: Role of A2B Receptors in Angiogenic Factor Regulation
Igor Feoktistov,Anna E. Goldstein,Sergey Ryzhov,Dewan Zeng,Luiz Belardinelli,Tatyana A. Voyno-Yasenetskaya,Italo Biaggioni +6 more
TL;DR: A2B receptors, predominantly expressed in human microvascular cells, modulate expression of angiogenic factors via coupling to Gq, and possibly via G12/13.
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RhoA Interaction with Inositol 1,4,5-Trisphosphate Receptor and Transient Receptor Potential Channel-1 Regulates Ca2+ Entry ROLE IN SIGNALING INCREASED ENDOTHELIAL PERMEABILITY
Dolly Mehta,Gias U. Ahmmed,Biman C. Paria,Michael Holinstat,Tatyana A. Voyno-Yasenetskaya,Chinnaswamy Tiruppathi,Richard D. Minshall,Asrar B. Malik +7 more
TL;DR: This paper showed that Rho activation signals interaction of IP3R with TRPC1 at the plasma membrane of endothelial cells, and triggers Ca2+ entry following store depletion and the resultant increase in endothelial permeability.
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G protein subunit Gα13 binds to integrin αIIbβ3 and mediates integrin “outside-in” signaling
Haixia Gong,Bo Shen,Panagiotis Flevaris,Christina Chow,Stephen C.-T. Lam,Tatyana A. Voyno-Yasenetskaya,Tohru Kozasa,Xiaoping Du +7 more
TL;DR: It is found that integrins are noncanonical Gα13-coupled receptors that provide a mechanism for dynamic regulation of RhoA and are coupled to intracellular signaling by direct binding to G proteins.
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Regulation of surfactant secretion in alveolar type II cells.
TL;DR: Signal transduction pathways involved in regulation of these processes are discussed as well as disorders associated with their malfunction, and lamellar bodies-independent secretion is also considered.