Terry C. Orton

TL;DR: The identity of Alamar Blue is shown as resazurin, a very simple and versatile way of measuring cell proliferation and cytotoxicity that presents numerous advantages over other cytot toxicity or proliferation tests but there are several drawbacks to the routine use.

TL;DR: This work has identified point mutations in the remaining allele of 25% of human hepatocellular carcinomas (HCCs) with LOH that give rise to truncated receptor protein and significant amino acid substitutions, and provide evidence that the M6P/IGF2R gene functions as a tumour suppressor in human liver carcinogenesis.

TL;DR: Evidence is provided that a common mechanism and domain organization may be used for juxtapositioned, reciprocally imprinted genes on human chromosome 14q32, and many of the predicted structural and regulatory features of the DLK1/GTL2 domain are highly analogous to those implicated in IGF2/H19 imprint regulation.

TL;DR: The molecular weights and spectral properties of these cytochrome P-450 fractions are reported, along with the phenobarbitone-induced form of the enzyme and the nature of the cytochromes induced by clofibrate pretreatment are discussed in the terms of possible haemoprotein heterogeneity.

TL;DR: Data establish the possibility in principle that inhibition of HMG-CoA reductase by statins in proximal tubule cells may reduce tubular protein reabsorption and cause reduced prenylation and thereby decreased function of one or more GTP-binding proteins.