T
Terry Smith
Researcher at Leiden University Medical Center
Publications - 16
Citations - 1268
Terry Smith is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Opioid & Morphine-6-glucuronide. The author has an hindex of 12, co-authored 16 publications receiving 1070 citations.
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Journal ArticleDOI
Incidence, Reversal, and Prevention of Opioid-induced Respiratory Depression.
TL;DR: The clinical approach to severe opioid-induced respiratory depression is to titrate naloxone to effect and continue treatment by continuous infusion until chances for renarcotization have diminished.
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Non-Analgesic Effects of Opioids: Opioid-induced Respiratory Depression
TL;DR: A novel approach is aimed at the reduction of respiratory depression from opioid-activation of (micro-)glia cells in the pons and brainstem using micro-glia cell stabilizers which seems an attractive alternative to the classical reversal strategies with naloxone.
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Opioid-induced respiratory depression in paediatrics: a review of case reports
TL;DR: An analysis of case reports on opioid-induced respiratory depression in paediatrics yields an important insight in the development of OIRD, with specific risk factors clearly present in the data.
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Ketamine for the treatment of chronic non-cancer pain.
TL;DR: There is now evidence form a limited number of studies that pain relief lasting for months is observed after long-term intravenous ketamine infusion, suggesting a modulatory effect of ketamine in the process of chronic pain, possibly via blockade of upregulated NMDAR.
Journal ArticleDOI
Averting Opioid-induced Respiratory Depression without Affecting Analgesia
Albert Dahan,Rutger van der Schrier,Terry Smith,Leon Aarts,Monique van Velzen,Marieke Niesters +5 more
TL;DR: None of the experimental drugs are adequate for therapeutic use in opioid-induced respiratory depression and all need further study of efficacy and toxicity, but all do highlight potential mechanisms of action and possible templates for further study and development.