M
Monique van Velzen
Researcher at Leiden University Medical Center
Publications - 88
Citations - 2146
Monique van Velzen is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Medicine & Opioid. The author has an hindex of 25, co-authored 60 publications receiving 1414 citations. Previous affiliations of Monique van Velzen include Leiden University & Erasmus University Rotterdam.
Papers
More filters
Journal ArticleDOI
An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia
Tine van de Donk,Marieke Niesters,Mikael A. Kowal,Erik Olofsen,Albert Dahan,Monique van Velzen +5 more
TL;DR: This experimental trial shows the complex behavior of inhaled cannabinoids in chronic pain patients with just small analgesic responses after a single inhalation, indicative of synergistic pharmacokinetic but antagonistic pharmacodynamic interactions of THC and CBD.
Journal ArticleDOI
ARA 290, a nonerythropoietic peptide engineered from erythropoietin, improves metabolic control and neuropathic symptoms in patients with type 2 diabetes.
Michael Brines,Ann Dunne,Monique van Velzen,P.L. Proto,Claes-Göran Östenson,Rita I Kirk,Ioannis N. Petropoulos,Ioannis N. Petropoulos,Saad Ahmed Javed,Rayaz A. Malik,Rayaz A. Malik,Anthony Cerami,Albert Dahan +12 more
TL;DR: Observations suggest that ARA 290 may benefit both metabolic control and neuropathy in subjects with type 2 diabetes and deserves continued clinical evaluation.
Journal ArticleDOI
Acyclovir Prophylaxis Predisposes to Antiviral Resistant Recurrent Herpetic Keratitis
Monique van Velzen,David A. M. C. van de Vijver,Freek B. van Loenen,Albert D. M. E. Osterhaus,Lies Remeijer,Georges M. G. M. Verjans +5 more
TL;DR: The data suggest that long-term ACV prophylaxis predisposes to ACV-refractory disease due to the emergence of corneal ACV(R) HSV-1, andACV-susceptibility testing is warranted during follow-up of rHK patients.
Journal ArticleDOI
Local CD4 and CD8 T-cell reactivity to HSV-1 antigens documents broad viral protein expression and immune competence in latently infected human trigeminal ganglia.
Monique van Velzen,Lichen Jing,Albert D. M. E. Osterhaus,Alessandro Sette,David M. Koelle,Georges M. G. M. Verjans +5 more
TL;DR: Intra-TG retention of virus-specific CD4 T-cells, validated to the HSV-1 peptide level, implies trafficking of viral proteins from neurons to HLA class II-expressing non-neuronal cells for antigen presentation.
Journal ArticleDOI
Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain
Daniel A. Culver,Albert Dahan,Daiva Bajorunas,Maria Jeziorska,Monique van Velzen,Leon Aarts,Jinny Tavee,Martijn R. Tannemaat,Ann Dunne,Rita I Kirk,Ioannis N. Petropoulos,Anthony Cerami,Rayaz A. Malik,Michael Brines +13 more
TL;DR: The relationships between CNFA and other clinical measures of disease support its use as a surrogate endpoints for disease modification, pain severity, and functional capacity to assess potential disease modifying therapies for neuropathy.