T
Tetsuya Taga
Researcher at Osaka University
Publications - 14
Citations - 8682
Tetsuya Taga is an academic researcher from Osaka University. The author has contributed to research in topics: Signal transduction & Glycoprotein 130. The author has an hindex of 14, co-authored 14 publications receiving 8465 citations. Previous affiliations of Tetsuya Taga include Tokyo Medical and Dental University & Bristol-Myers Squibb.
Papers
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Journal ArticleDOI
Gp130 and the interleukin-6 family of cytokines
Tetsuya Taga,Tadamitsu Kishimoto +1 more
TL;DR: This paper reviews recent progress in the study of the interleukin-6 family of cytokines and gp130 and describes how the dimerization of gp130 leads to activation of associated cytoplasmic tyrosine kinases and subsequent modification of transcription factors.
Book ChapterDOI
Interleukin-6 in biology and medicine
TL;DR: Application of IL-6 is promising in cancer treatment as well as in treatment of radiation- or chemotherapy-induced myelosuppression and the cell biology of the intracellular events that link transduction to gene regulation is an important area, and work on these topics helps to understand such phenomena as multifunction of IL -6 and bidirectional effects of cell growth depending on the cell type.
Journal ArticleDOI
Structure and function of a new STAT-induced STAT inhibitor
Tetsuji Naka,Masashi Narazaki,Moritoshi Hirata,Tomoshige Matsumoto,Seijiro Minamoto,Atsufumi Aono,Norihiro Nishimoto,Tadahiro Kajita,Tetsuya Taga,Kazuyuki Yoshizaki,Shizuo Akira,Tadamitsu Kishimoto +11 more
TL;DR: It is found that SSI-1 messenger RNA was induced by the cytokines interleukins 4 and 6, leukaemia-inhibitory factor (LIF), and granulocyte colony-stimulating factor (G-CSF), and these findings indicate that SSi-1 is responsible for negative-feedback regulation of the JAK–STAT pathway induced by cytokine stimulation.
Journal ArticleDOI
Molecular cloning and expression of an IL-6 signal transducer, gp130
Masahiko Hibi,Masaaki Murakami,Mikiyoshi Saito,Toshio Hirano,Tetsuya Taga,Tadamitsu Kishimoto +5 more
TL;DR: A cloned gp130 could associate with a complex of IL-6 and solubleIL-6-R and transduce the growth signal when expressed in a murine IL-3-dependent cell line and confirmed that a gp130 is involved in the formation of high affinity IL- 6 binding sites.
Journal ArticleDOI
Cytokine signal transduction
TL;DR: Clinical Cancer Research is published monthly, one volume per year, by the American Association for Cancer Research, Inc.