Tetsuya Tatsuta

TL;DR: It is suggested that CA reduces Aβ42 production by activating TACE without promoting BACE1 in human neuroblastoma cells and the use of CA may have a potential in the prevention of Aβ-mediated diseases, particularly AD.

TL;DR: Examination of the effect of polyinosinic-polycytidylic acid (poly IC), an authentic double-stranded RNA (dsRNA) that mimics viral dsRNAs) on MDA5 expression using primary culture of human mesangial cells found it to be involved not only in physiological antiviral reactions but also in chronic inflammation in glomerular mesangials cells.

TL;DR: Although bradycardia was more frequently observed in the elderly patients during ESD in this study, ESD was performed safely and managed appropriately, with infrequent postoperative complications, and appears to be effective, even in elderly patients.

TL;DR: It is demonstrated that TLR4 signaling, induced by LPS, increases the expression of melanoma differentiation-associated gene 5 (MDA5) and interferon (IFN)-stimulated gene 56 (ISG56) in U373MG human astrocytoma cells, and RNA interference experiments revealed that MDA5 and ISG56 positively regulate the LPS-induced expression of a chemokine CXCL10, but not CCL2.

TL;DR: Results suggest that ISG54 and ISG56 are involved in the induction of CXCL10 in TLR3/IFN-β signaling at least partly by co-operating with RIG-I and MDA5, and may play an important role both in antiviral immunity and in neuroinflammatory diseases.