T
Theresa K. Kelly
Researcher at University of Southern California
Publications - 27
Citations - 8046
Theresa K. Kelly is an academic researcher from University of Southern California. The author has contributed to research in topics: DNA methylation & Chromatin. The author has an hindex of 19, co-authored 27 publications receiving 7369 citations. Previous affiliations of Theresa K. Kelly include University of California, Los Angeles.
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Epigenetics in Cancer
TL;DR: The current understanding of alterations in the epigenetic landscape that occur in cancer compared with normal cells, the roles of these changes in cancer initiation and progression, including the cancer stem cell model, and the potential use of this knowledge in designing more effective treatment strategies are discussed.
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Epigenetic modifications as therapeutic targets
TL;DR: The presence of multiple epigenetic aberrations within malignant tissue and the abilities of cells to develop resistance suggest that epigenetic therapies are most beneficial when combined with other anticancer strategies, such as signal transduction inhibitors or cytotoxic treatments.
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DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
Tina B. Miranda,Connie C. Cortez,Christine B. Yoo,Gangning Liang,Masanobu Abe,Theresa K. Kelly,Victor E. Marquez,Peter A. Jones +7 more
TL;DR: In this article, 3-deazaneplanocin A (DZNep) was reported to selectively inhibit trimethylation of lysine 27 on histone H3 (H3K27me3) and Lysine 20 on H4 (H4K20me3), and reactivate silenced genes in cancer cells.
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Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules
TL;DR: In this paper, the authors used a GpC methyltransferase (M.CviPI) and next generation sequencing to generate a high resolution footprint of nucleosome positioning genome-wide using less than 1 million cells.
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Differential Transport and Local Translation of Cytoskeletal, Injury-Response, and Neurodegeneration Protein mRNAs in Axons
Dianna E. Willis,Ka Wan Li,Jun-Qi Zheng,Jay H. Chang,August B. Smit,Theresa K. Kelly,Tanuja T. Merianda,James Sylvester,Jan van Minnen,Jeffery L. Twiss +9 more
TL;DR: In this paper, the authors used axons from cultures of injury-conditioned adult dorsal root ganglion (DRG) neurons and proteomics methodology to identify axonally synthesized proteins.