V
Victor E. Marquez
Researcher at National Institutes of Health
Publications - 420
Citations - 17527
Victor E. Marquez is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Protein kinase C & Diacylglycerol kinase. The author has an hindex of 69, co-authored 419 publications receiving 16509 citations. Previous affiliations of Victor E. Marquez include Government of the United States of America & Center for Advanced Biotechnology and Medicine.
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Journal ArticleDOI
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.
Damian B. Yap,Damian B. Yap,Justin Chu,Tobias Berg,Matthieu Schapira,S.-W. Grace Cheng,Annie Moradian,Ryan D. Morin,Andrew J. Mungall,Barbara Meissner,Merrill Boyle,Victor E. Marquez,Marco A. Marra,Randy D. Gascoyne,Randy D. Gascoyne,R. Keith Humphries,Cheryl H. Arrowsmith,Cheryl H. Arrowsmith,Gregg B. Morin,Samuel Aparicio,Samuel Aparicio +20 more
TL;DR: It is demonstrated, using in vitro enzyme assays of reconstituted PRC2 complexes, that Y641 mutations result in a decrease in monomethylation and an increase in trimethylation activity of the enzyme relative to the wild-type enzyme.
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DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
Tina B. Miranda,Connie C. Cortez,Christine B. Yoo,Gangning Liang,Masanobu Abe,Theresa K. Kelly,Victor E. Marquez,Peter A. Jones +7 more
TL;DR: In this article, 3-deazaneplanocin A (DZNep) was reported to selectively inhibit trimethylation of lysine 27 on histone H3 (H3K27me3) and Lysine 20 on H4 (H4K20me3), and reactivate silenced genes in cancer cells.
Journal ArticleDOI
Inhibition of DNA Methylation and Reactivation of Silenced Genes by Zebularine
Jonathan C. Cheng,Cindy B. Matsen,Felicidad A. Gonzales,Wei Ye,Sheldon Greer,Victor E. Marquez,Peter A. Jones,Eric U. Selker +7 more
TL;DR: Zebularine is a stable DNA demethylating agent and the first drug in its class able to reactivate an epigenetically silenced gene by oral administration.
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EZH2 Is Essential for Glioblastoma Cancer Stem Cell Maintenance
Mario-Luca Suvà,Nicolo Riggi,Michalina Janiszewska,Ivan Radovanovic,Paolo Provero,Jean-Christophe Stehle,Karine Baumer,Marie-Aude Le Bitoux,Denis Marino,Luisa Cironi,Victor E. Marquez,Virginie Clement,Ivan Stamenkovic +12 more
TL;DR: It is shown that targeted pharmacologic disruption of EZH2 by the S-adenosylhomocysteine hydrolase inhibitor 3-deazaneplanocin A (DZNep), or its specific downregulation by short hairpin RNA (shRNA), strongly impairs GBM cancer stem cell (CSC) self-renewal in vitro and tumor-initiating capacity in vivo.
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TNF/p38α/Polycomb Signaling to Pax7 Locus in Satellite Cells Links Inflammation to the Epigenetic Control of Muscle Regeneration
Daniela Palacios,Chiara Mozzetta,Silvia Consalvi,Giuseppina Caretti,Giuseppina Caretti,Valentina Saccone,Valentina Proserpio,Valentina Proserpio,Victor E. Marquez,Sergio Valente,Antonello Mai,Sonia Vanina Forcales,Vittorio Sartorelli,Pier Lorenzo Puri +13 more
TL;DR: An inflammation-activated signaling in muscle stem (satellite) cells is identified, by which the polycomb repressive complex 2 (PRC2) represses Pax7 expression during muscle regeneration, establishing the biological link between p38/ PRC2 signaling to Pax7 and satellite cell decision to proliferate or differentiate.