D
Daniel D. De Carvalho
Researcher at Princess Margaret Cancer Centre
Publications - 125
Citations - 8245
Daniel D. De Carvalho is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 32, co-authored 105 publications receiving 5562 citations. Previous affiliations of Daniel D. De Carvalho include University Health Network & State University of Campinas.
Papers
More filters
Journal ArticleDOI
DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts.
David Roulois,Helen Loo Yau,Helen Loo Yau,Rajat Singhania,Yadong Wang,Arnavaz Danesh,Shu Yi Shen,Han Han,Gangning Liang,Peter A. Jones,Trevor J. Pugh,Trevor J. Pugh,Catherine A. O’Brien,Catherine A. O’Brien,Catherine A. O’Brien,Daniel D. De Carvalho,Daniel D. De Carvalho +16 more
TL;DR: It is demonstrated that low-dose 5-AZA-CdR targets colorectal cancer-initiating cells (CICs) by inducing viral mimicry, and the MDA5/MAVS/IRF7 pathway is highlighted as a potentially druggable target against CICs.
Journal ArticleDOI
Gene Body Methylation Can Alter Gene Expression and Is a Therapeutic Target in Cancer
Xiaojing Yang,Han Han,Daniel D. De Carvalho,Daniel D. De Carvalho,Fides D. Lay,Peter A. Jones,Gangning Liang +6 more
TL;DR: It is shown that 5-aza-2'-deoxycytidine treatment not only reactivates genes but decreases the overexpression of genes, many of which are involved in metabolic processes regulated by c-MYC.
Journal ArticleDOI
Epigenetic modifications as therapeutic targets
TL;DR: The presence of multiple epigenetic aberrations within malignant tissue and the abilities of cells to develop resistance suggest that epigenetic therapies are most beneficial when combined with other anticancer strategies, such as signal transduction inhibitors or cytotoxic treatments.
Journal ArticleDOI
Sensitive tumour detection and classification using plasma cell-free DNA methylomes
Shu Yi Shen,Rajat Singhania,Gordon Fehringer,Ankur Chakravarthy,Michael H.A. Roehrl,Michael H.A. Roehrl,Michael H.A. Roehrl,Dianne Chadwick,Philip C. Zuzarte,Ayelet Borgida,Ting Ting Wang,Ting Ting Wang,Tiantian Li,Olena Kis,Zhen Zhao,Anna Spreafico,Tiago Medina,Yadon Wang,David Roulois,David Roulois,Ilias Ettayebi,Ilias Ettayebi,Zhuo Chen,Signy Chow,Tracy Murphy,Andrea Arruda,Grainne M. O'Kane,Jessica Liu,Mark Mansour,John Douglas Mcpherson,Catherine A. O’Brien,Natasha B. Leighl,Philippe L. Bedard,Neil E. Fleshner,Geoffrey Liu,Geoffrey Liu,Mark D. Minden,Steven Gallinger,Steven Gallinger,Anna Goldenberg,Trevor J. Pugh,Trevor J. Pugh,Michael M. Hoffman,Michael M. Hoffman,Scott V. Bratman,Scott V. Bratman,Rayjean J. Hung,Rayjean J. Hung,Daniel D. De Carvalho,Daniel D. De Carvalho +49 more
TL;DR: An immunoprecipitation-based protocol is developed to analyse DNA methylation in small quantities of circulating cell-free DNA, and can detect and classify cancers in plasma samples from several tumour types.
Journal ArticleDOI
LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade
Wanqiang Sheng,Wanqiang Sheng,Martin W. LaFleur,Thao H. Nguyen,Sujun Chen,Sujun Chen,Ankur Chakravarthy,Ankur Chakravarthy,Jake Conway,Ying Li,Hao Chen,Hao Chen,Henry Yang,Pang-Hung Hsu,Eliezer M. Van Allen,Gordon J. Freeman,Daniel D. De Carvalho,Daniel D. De Carvalho,Housheng Hansen He,Housheng Hansen He,Arlene H. Sharpe,Arlene H. Sharpe,Yang Shi,Yang Shi +23 more
TL;DR: It is demonstrated that ablation of the histone demethylase LSD1 in cancer cells increases repetitive element expression, including endogenous retroviral elements (ERVs), and decreases expression of RNA-induced silencing complex (RISC) components.