T
Thierry Fest
Researcher at French Institute of Health and Medical Research
Publications - 47
Citations - 2032
Thierry Fest is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Diffuse large B-cell lymphoma & Lymphoma. The author has an hindex of 22, co-authored 47 publications receiving 1669 citations. Previous affiliations of Thierry Fest include University of Rennes.
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Journal ArticleDOI
Next Generation Sequencing in Diffuse Large B Cell Lymphoma Highlights Molecular Divergence and Therapeutic Opportunities: a LYSA Study
Sydney Dubois,Pierre-Julien Viailly,Sylvain Mareschal,Elodie Bohers,Philippe Bertrand,Philippe Ruminy,Catherine Maingonnat,Jean-Philippe Jais,Pauline Peyrouze,Martin Figeac,Thierry Jo Molina,Fabienne Desmots,Thierry Fest,Corinne Haioun,Thierry Lamy,Christiane Copie-Bergman,Josette Brière,Tony Petrella,Danielle Canioni,Bettina Fabiani,Bertrand Coiffier,Richard Delarue,Frederic Peyrade,André Bosly,Marc André,Nicolas Ketterer,Gilles Salles,Hervé Tilly,Karen Leroy,Fabrice Jardin +29 more
TL;DR: This study demonstrates the contribution of NGS with a consensus gene panel to personalized therapy in DLBCL, highlighting the molecular heterogeneity of subtypes and identifying somatic mutations with therapeutic and prognostic impact.
Journal ArticleDOI
Characterization of intratumoral follicular helper T cells in follicular lymphoma: role in the survival of malignant B cells.
Patricia Amé-Thomas,J. Le Priol,J. Le Priol,H Yssel,Gersende Caron,Céline Pangault,Rachel Jean,Nadine Martin,Teresa Marafioti,P. Gaulard,Thierry Lamy,Thierry Fest,G. Semana,G. Semana,Karin Tarte +14 more
TL;DR: This study demonstrates that tumor-infiltrating CD4pos T cells are more heterogeneous than previously presumed, and underlines for the first time the crucial role of TFH in the complex set of cellular interactions within FL microenvironment.
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Early Expansion of Circulating Granulocytic Myeloid-derived Suppressor Cells Predicts Development of Nosocomial Infections in Patients with Sepsis.
Fabrice Uhel,Imane Azzaoui,Murielle Gregoire,Céline Pangault,Joelle Dulong,Jean-Marc Tadié,Arnaud Gacouin,Christophe Camus,Luc Cynober,Thierry Fest,Yves Le Tulzo,Mikael Roussel,Karin Tarte +12 more
TL;DR: G‐MDSCs producing arginase 1 are associated with a higher incidence of nosocomial infections and seem to be major actors of sepsis‐induced immune suppression.
Journal ArticleDOI
Characterization of a Transitional Preplasmablast Population in the Process of Human B Cell to Plasma Cell Differentiation
Michel Jourdan,Anouk Caraux,Gersende Caron,Nicolas Robert,Geneviève Fiol,Thierry Rème,Karine Bollore,Jean-Pierre Vendrell,Simon Le Gallou,Frédéric Mourcin,John De Vos,John De Vos,Alboukadel Kassambara,Christophe Duperray,Dirk Hose,Thierry Fest,Karin Tarte,Bernard Klein,Bernard Klein +18 more
TL;DR: The findings show the existence of a transitional preplasmablast population using an in vitro model of plasma cell generation and of its in vivo counterpart in various lymphoid tissues.
Journal ArticleDOI
GenomicScape: an easy-to-use web tool for gene expression data analysis. Application to investigate the molecular events in the differentiation of B cells into plasma cells.
Alboukadel Kassambara,Thierry Rème,Michel Jourdan,Thierry Fest,Dirk Hose,Karin Tarte,Bernard Klein +6 more
TL;DR: It is shown how easily GenomicScape makes it possible to construct a molecular atlas of the B cell differentiation using publicly available transcriptome data of naïve B cells, centreroblasts, centrocytes, memory B Cells, preplasmablasts, plasmablast, early plasma cells and bone marrow plasma cells.