T
Thierry Livache
Researcher at University of Grenoble
Publications - 160
Citations - 4118
Thierry Livache is an academic researcher from University of Grenoble. The author has contributed to research in topics: Surface plasmon resonance & Biosensor. The author has an hindex of 38, co-authored 155 publications receiving 3793 citations. Previous affiliations of Thierry Livache include Commissariat à l'énergie atomique et aux énergies alternatives & French Alternative Energies and Atomic Energy Commission.
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Journal ArticleDOI
Preparation of a DNA matrix via an electrochemically directed copolymerization of pyrrole and oligonucleotides bearing a pyrrole group.
TL;DR: A new methodology for the preparation of addressed DNA matrices is described, which includes an electrochemically directed copolymerization of pyrrole and oligonucleotides bearing on their 5' end a pyr role moiety introduced by phosphoramidite chemistry.
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Polypyrrole DNA chip on a silicon device: example of hepatitis C virus genotyping.
Thierry Livache,Brigitte Fouque,Andre Roget,Joseph Marchand,Gérard Bidan,Robert Teoule,Gérard Mathis +6 more
TL;DR: An oligonucleotide array constructed on a silicon device bearing a matrix of addressable 50-microns microelectrodes that was successfully applied to the genotyping of hepatitis C virus in blood samples shows good sensitivity and a high degree of dimensional resolution.
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Characterization and optimization of a real-time, parallel, label-free, polypyrrole-based DNA sensor by surface plasmon resonance imaging.
Philippe Guedon,Thierry Livache,Francoise Martin,Frederic Lesbre,André Roget,Gérard Bidan,Yves Levy +6 more
TL;DR: A methodology to quantify multispot parallel DNA hybridizations and denaturations on gold surfaces by using a polypyrrole-based surface functionalization based on an electrospotting process and surface plasmon resonance imaging allowing real-time measurements on several DNA spots at a time is described.
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Chemical synthesis of a biologically active natural tRNA with its minor bases.
Didier Gasparutto,Thierry Livache,Hervé Bazin,Anne-Marie Duplaa,A. Guy,Alexander Khorlin,D. Molko,André Roget,Robert Teoule +8 more
TL;DR: The complete chemical synthesis of an E. coli tRNA(Ala) with its specific minor nucleosides, dihydrouridine, ribothymidine and pseudouridine; transcribed into cDNA by reverse transcriptase and sequenced.
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Temperature effects on DNA chip experiments from surface plasmon resonance imaging: isotherms and melting curves.
TL;DR: The effects of the probe length on the Hybridization thermodynamics, deduced from the temperature dependence of the reaction constants as well as from the melting curves, suggest dispersion in the length of the hybridization segments of the probes accessible to the targets.