Thomas A. Mably

TL;DR: When administered in overtly toxic doses to postpubescent rats, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) produces a variety of adverse effects on the male reproductive system including a decrease in plasma androgen concentrations as mentioned in this paper.

TL;DR: Results are not inconsistent with the pronounced reductions in daily sperm production and cauda epididymal sperm reserves caused by perinatal TCDD exposure since rats produce and ejaculate far more sperm than are required for normal fertility.

TL;DR: In utero and lactational exposure to small amounts of TCDD demasculinizes and feminizes male rats, and the LH secretory responsiveness of the hypothalamic/pituitary axis to ovarian steroids was assessed.

TL;DR: It was found that TCDD treatment decreased gastric acid secretion as determined by decreases in gastric secretory volume, acidity, and total acid output in pylorus-ligated rats, and it was concluded that the most probable cause of hypergastrinemia in T CDD-treated rats is decreased gastrics acid secretion.

TL;DR: It is demonstrated that in utero and lactational TCDD exposure impairs sexual differentiation of the central nervous system and the regulation of LH secretion was feminized.