T
Thomas D. Schneider
Researcher at National Institutes of Health
Publications - 122
Citations - 12274
Thomas D. Schneider is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & Information theory. The author has an hindex of 44, co-authored 110 publications receiving 11719 citations. Previous affiliations of Thomas D. Schneider include Penn State Milton S. Hershey Medical Center & Jawaharlal Nehru University.
Papers
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Journal ArticleDOI
Sequence logos: a new way to display consensus sequences
Thomas D. Schneider,R M Stephens +1 more
TL;DR: From these 'sequence logos', one can determine not only the consensus sequence but also the relative frequency of bases and the information content at every position in a site or sequence.
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Information content of binding sites on nucleotide sequences
TL;DR: Comparisons between R sequence and R frequency suggest that the information at binding sites is just sufficient for the sites to be distinguished from the rest of the genome.
Journal ArticleDOI
Translational Initiation in Prokaryotes
TL;DR: A conceptual framework for developing a theory of translational initiation and three approaches to a higher order approximation are described.
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Use of the ‘Perceptron’ algorithm to distinguish translational initiation sites in E. coli
TL;DR: A "Perceptron" algorithm is used to find a weighting function which distinguishes E. coli translational initiation sites from all other sites in a library of over 78,000 nucleotides of mRNA sequence.
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Characterization of translational initiation sites in E. coli.
TL;DR: The Shine and Dalgarno sequence of 124 known gene beginnings is characterized and this information is used to make "rules" which help distinguish gene beginning from other sites in a library of over 78,000 bases of mRNA.