Larry Gold

TL;DR: High-affinity nucleic acid ligands for a protein were isolated by a procedure that depends on alternate cycles of ligand selection from pools of variant sequences and amplification of the bound species.

TL;DR: A versatile and powerful tool that allows large-scale comparison of proteome profiles among discrete populations, which will enable the discovery of novel biomarkers in a manner that is unencumbered by the incomplete knowledge of biology, thereby helping to advance the next generation of evidence-based medicine.

TL;DR: Comparisons between R sequence and R frequency suggest that the information at binding sites is just sufficient for the sites to be distinguished from the rest of the genome.

TL;DR: The range of applications of this technology for new discovery extends from basic research reagents to the identification of novel diagnostic and therapeutic reagents, and examples of these applications are described.

TL;DR: The SELEX (Systematic Evolution of Ligands by EXponential Enrichment) method as discussed by the authors was proposed for the identification of nucleic acid ligands, where a candidate mixture of single stranded nucleic acids having regions of randomized sequence is contacted with a target compound and those nucleic amino acids having an increased affinity to the target are partitioned from the remainder of the candidate mixture.