T
Thomas Frielle
Researcher at Howard Hughes Medical Institute
Publications - 14
Citations - 2719
Thomas Frielle is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Receptor & Beta-1 adrenergic receptor. The author has an hindex of 9, co-authored 14 publications receiving 2681 citations. Previous affiliations of Thomas Frielle include University of Pittsburgh & Yale University.
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Journal ArticleDOI
Cloning of the gene and cDNA for mammalian β -adrenergic receptor and homology with rhodopsin
Richard A. F. Dixon,Brian K. Kobilka,David J. Strader,Jeffrey L. Benovic,Henrik G. Dohlman,Thomas Frielle,Mark A. Bolanowski,Carl D. Bennett,Elaine Rands,Ronald E. Diehl,Richard A. Mumford,Eve E. Slater,Irving S. Sigal,Marc G. Caron,Robert J. Lefkowitz,Catherine D. Strader +15 more
TL;DR: Cloning of the gene and cDNA for the mammalian β2AR indicates significant amino-acid homology with bovine rhodopin and suggests that, like rhodopsin7, βAR possesses multiple membrane-spanning regions.
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Cloning of the cDNA for the human beta 1-adrenergic receptor.
Thomas Frielle,Sheila Collins,Kiefer W. Daniel,Marc G. Caron,Robert J. Lefkowitz,Brian K. Kobilka +5 more
TL;DR: RNA blot analysis indicates a message of 2.5 kilobases in rat tissues, with a pattern of tissue distribution consistent with beta 1AR binding, which suggests that the avian gene encoding beta AR and the human gene encodingbeta 1AR evolved from a common ancestral gene.
Journal ArticleDOI
An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins
Brian K. Kobilka,Thomas Frielle,Sheila Collins,Theresa Yang-Feng,Tong Sun Kobilka,Uta Francke,Robert J. Lefkowitz,Marc G. Caron +7 more
TL;DR: A DNA fragment in the human genome is cloned and sequenced which cross-hybridizes with a full-length β2-adrenergic receptor probe at reduced stringency and appears to be intronless, containing an uninterrupted long open reading frame which encodes a putative protein with all the expected structural features of a G-protein-coupled receptor.
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Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors
TL;DR: Several of the membrane-spanning regions appear to be involved in the determination of receptor subtype specificity, presumably by formation of a ligand-binding pocket, with determinants for agonist and antagonist binding being distinguishable.
Journal ArticleDOI
Chromosomal organization of adrenergic receptor genes.
Teresa L. Yang-Feng,Feiyu Xue,Wuwei Zhong,Susanna Cotecchia,Thomas Frielle,Marc G Caron,Robert J. Lefkowitz,Uta Francke +7 more
TL;DR: The alpha 1- AR gene is mapped to chromosome 5q32----q34, the same position as beta 2-AR, and the beta 1-AR gene to chromosome 10q24----q26, the region where alpha 2- AR is located, as well as the sequence similarity that exists among all the ARs.