Eve E. Slater

TL;DR: Cloning of the gene and cDNA for the mammalian β2AR indicates significant amino-acid homology with bovine rhodopin and suggests that, like rhodopsin7, βAR possesses multiple membrane-spanning regions.

TL;DR: Based on data from three studies with complete recording of adverse events in about 12,000 patients each, it was determined that angioedema in association with the angiotensin converting-enzyme inhibitor enalapril maleate occurred during the first week of therapy at the rate of one case per 3000 patients per week.

TL;DR: An inhibitor of the insulin receptor tyrosine kinase (IRTK), (hydroxy-2-naphthalenyl-methyl) phosphonic acid, was designed and synthesized and was shown to be an inhibitors of the biological effects of insulin in vitro.

TL;DR: Vanadate's insulin-mimetic effect on mouse diaphragm glycogenesis occurs at a site distal to the insulin receptor, suggesting that vanadate’s insulin-receptor activation by in vivo Vanadate administration is based on a conformational change in the receptor beta-subunit upon autophosphorylation.

TL;DR: The objective in the clinical use of these inhibitors is to normalise plasma cholesterol levels in hypercholesterolaemic individuals, which contrasts with the profound reductions in cholesterol obtained when normocholesterolemic animals are treated by the high doses of these drugs required for toxicological assessment.