Mark A. Bolanowski

TL;DR: Cloning of the gene and cDNA for the mammalian β2AR indicates significant amino-acid homology with bovine rhodopin and suggests that, like rhodopsin7, βAR possesses multiple membrane-spanning regions.

TL;DR: A cDNA encoding the human beta 2-adrenergic receptor is isolated and sequenced, showing the most highly conserved regions are the putative transmembrane helices and cytoplasmic loops, suggesting that these regions of the molecule harbor important functional domains.

TL;DR: A detailed characterization of its complete gene in both the human and hamster which reveals several unusual and provocative features suggest that the beta 2-adrenergic receptor may have arisen as a processed gene for another related gene.

TL;DR: The results establish the presence of elements within the proximal promoter region of the beta 2AR gene responsible for the transcriptional enhancing activity of cAMP and demonstrate that beta 2 AR gene expression is regulated by a type of feedback mechanism involving the second messenger cAMP.

TL;DR: In the last few years the genes for several of these receptors have been cloned and advances now permit a closer examination of the physical structure and the opportunity to examine directly their genetic regulation.