T
Thomas G. Fanning
Researcher at Armed Forces Institute of Pathology
Publications - 50
Citations - 4991
Thomas G. Fanning is an academic researcher from Armed Forces Institute of Pathology. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 28, co-authored 50 publications receiving 4805 citations. Previous affiliations of Thomas G. Fanning include University of California, Davis & University of Cologne.
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Journal ArticleDOI
Characterization of the 1918 influenza virus polymerase genes
Jeffery K. Taubenberger,Ann H. Reid,Ann H. Reid,Raina M. Lourens,Raina M. Lourens,Ruixue Wang,Guozhong Jin,Thomas G. Fanning +7 more
TL;DR: In this article, the authors present sequence and phylogenetic analyses of the complete genome of the 1918 influenza virus and propose that the 1918 virus was not a reassortant virus (like those of the 1957 and 1968 pandemics), but more likely an entirely avian-like virus that adapted to humans.
Journal ArticleDOI
Initial Genetic Characterization of the 1918 “Spanish” Influenza Virus
TL;DR: A novel H1N1 influenza A virus that belongs to the subgroup of strains that infect humans and swine, not the avian subgroup is identified.
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Origin and evolution of the 1918 “Spanish” influenza virus hemagglutinin gene
TL;DR: Phylogenetic analyses suggest that the 1918 virus HA gene, although more closely related to avian strains than any other mammalian sequence, is mammalian and may have been adapting in humans before 1918.
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Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes
Christopher F. Basler,Ann H. Reid,Jody K. Dybing,Thomas A. Janczewski,Thomas G. Fanning,Hongyong Zheng,Mirella Salvatore,Michael L. Perdue,David E. Swayne,Adolfo García-Sastre,Peter Palese,Jeffery K. Taubenberger +11 more
TL;DR: The sequence of the A/Brevig Mission/1/18 (H1N1) virus nonstructural (NS) segment encoding two proteins, NS1 and nuclear export protein is reported, suggesting that interaction of the NS1 protein with host-cell factors plays a significant role in viral pathogenesis.
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Characterization of the 1918 "Spanish" influenza virus neuraminidase gene.
TL;DR: The complete coding sequence of the neuraminidase gene of the 1918 virus is determined and appears to be intermediate between mammals and birds, suggesting that it was introduced into mammals just before the 1918 pandemic.