D
David E. Swayne
Researcher at United States Department of Agriculture
Publications - 384
Citations - 26650
David E. Swayne is an academic researcher from United States Department of Agriculture. The author has contributed to research in topics: Influenza A virus subtype H5N1 & Virus. The author has an hindex of 85, co-authored 378 publications receiving 24842 citations. Previous affiliations of David E. Swayne include World Health Organization & Ohio Agricultural Research and Development Center.
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Journal ArticleDOI
Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness.
Kanta Subbarao,Alexander Klimov,Alexander Klimov,Alexander Klimov,Jacqueline M. Katz,Jacqueline M. Katz,Jacqueline M. Katz,Helen L. Regnery,Helen L. Regnery,Helen L. Regnery,Wilina Lim,Wilina Lim,Wilina Lim,Henrietta Hall,Henrietta Hall,Henrietta Hall,Michael L. Perdue,Michael L. Perdue,Michael L. Perdue,David E. Swayne,David E. Swayne,David E. Swayne,Catherine A. Bender,Catherine A. Bender,Catherine A. Bender,Jing Huang,Jing Huang,Jing Huang,Mark L. Hemphill,Mark L. Hemphill,Mark L. Hemphill,Thomas Rowe,Thomas Rowe,Thomas Rowe,Michael W. Shaw,Michael W. Shaw,Michael W. Shaw,Xiyan Xu,Xiyan Xu,Xiyan Xu,Keiji Fukuda,Keiji Fukuda,Keiji Fukuda,Nancy Cox,Nancy Cox,Nancy Cox +45 more
TL;DR: An avian H5N1 influenza A virus was isolated from a tracheal aspirate obtained from a 3-year-old child in Hong Kong with a fatal illness consistent with influenza, causing 87.5 to 100 percent mortality in experimentally inoculated White Plymouth Rock and White Leghorn chickens.
Journal ArticleDOI
Characterization of the reconstructed 1918 Spanish influenza pandemic virus
Terrence M. Tumpey,Christopher F. Basler,Patricia V. Aguilar,Hui Zeng,Alicia Solórzano,David E. Swayne,Nancy J. Cox,Jacqueline M. Katz,Jeffery K. Taubenberger,Peter Palese,Adolfo García-Sastre +10 more
TL;DR: Reverse genetics was used to generate an influenza virus bearing all eight gene segments of the pandemic virus to study the properties associated with its extraordinary virulence, and confirmed that the coordinated expression of the 1918 virus genes most certainly confers the unique high-virulence phenotype observed with this pandemicirus.
Journal ArticleDOI
Highly pathogenic avian influenza.
David E. Swayne,David L. Suarez +1 more
TL;DR: Control programmes, which imply allowing a low incidence of infection, are not an acceptable method for managing HPAI, but have been used during some outbreaks of MPAI.
Journal ArticleDOI
Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus
John C. Kash,Terrence M. Tumpey,Sean Proll,Victoria S. Carter,Olivia Perwitasari,Matthew J. Thomas,Christopher F. Basler,Peter Palese,Jeffery K. Taubenberger,Jeffery K. Taubenberger,Adolfo García-Sastre,David E. Swayne,Michael G. Katze +12 more
TL;DR: It is found that mice infected with a virus containing all eight genes from the pandemic virus showed marked activation of pro-inflammatory and cell-death pathways by 24 h after infection that remained unabated until death on day 5, in contrast with smaller host immune responses as measured at the genomic level.
Journal ArticleDOI
A Two-Amino Acid Change in the Hemagglutinin of the 1918 Influenza Virus Abolishes Transmission
Terrence M. Tumpey,Taronna R. Maines,Neal Van Hoeven,Laurel Glaser,Alicia Solórzano,Claudia Pappas,Claudia Pappas,Nancy J. Cox,David E. Swayne,Peter Palese,Jacqueline M. Katz,Adolfo García-Sastre +11 more
TL;DR: These findings confirm an essential role of hemagglutinin receptor specificity for the transmission of influenza viruses among mammals and suggest that a predominant human α-2,6 sialic acid binding preference is essential for optimal transmission of this pandemic virus.