Thomas Graven-Nielsen

TL;DR: OA patients showed a significant facilitation of temporal summation from both the knee and TA and had significantly less DNIC as compared with controls, and the importance of central sensitization as an important manifestation in knee OA is highlighted.

TL;DR: The aim of this Review is to give a short presentation of the manifestations, assessment methods, and mechanisms underlying localized and widespread musculoskeletal pain, deep somatic tissue hyperalgesia and chronification.

TL;DR: Clinical and experimental findings indicate that musculoskeletal pain modulates motor performance during gait probably via reflex pathways, and new possibilities to monitor and investigate altered motor performance may help to develop more rational therapies for CLBP patients.

TL;DR: Tonic muscle pain can inhibit the motor system and is followed by a reduction of the excitability of both cortical and spinal motoneurones.

TL;DR: The present study showed that mechanisms involved in referred pain, temporal summation, muscular hyperalgesia, and muscle pain at rest were attenuated by the NMDA‐antagonist in FMS patients, and suggested a link between central hyperexcitability and the mechanisms for facilitated referred pain and temporal summary in a sub‐group of the fibromyalgia syndrome patients.