T
Thomas Lo
Researcher at University of Cambridge
Publications - 3
Citations - 797
Thomas Lo is an academic researcher from University of Cambridge. The author has contributed to research in topics: Homologous recombination & DNA repair. The author has an hindex of 3, co-authored 3 publications receiving 758 citations.
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Journal ArticleDOI
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex
Luca Pellegrini,David S. Yu,Thomas Lo,Shubha Anand,Miyoung Lee,Tom L. Blundell,Ashok R. Venkitaraman +6 more
TL;DR: The BRC repeat mimics a motif in RAD51 that serves as an interface for oligomerization between individual RAD51 monomers, thus enabling BRCA2 to control the assembly of the RAD51 nucleoprotein filament, which is essential for strand-pairing reactions during DNA recombination.
Journal ArticleDOI
Sequence fingerprints in BRCA2 and RAD51: implications for DNA repair and cancer
TL;DR: Conserved BRC repeat and RAD51 sequence fingerprints across a wide range of eukaryotic species substantiates the functional significance of the BRCA2-RAD51 interactions and suggests a possible model for the participation of BRC a2 in RAD51 nucleoprotein filament formation.
Book ChapterDOI
Asymmetry in the Multiprotein Systems of Molecular Biology
Tom L. Blundell,Victor M. Bolanos-Garcia,Dimitri Y. Chirgadze,Nicholas J. Harmer,Thomas Lo,Luca Pellegrini,B. Lynn Sibanda +6 more
TL;DR: Symmetry is, however, often broken, presumably to create more sensitivity and specificity in the signaling system by assembling other components, into higher-order multiprotein systems.