D
David S. Yu
Researcher at Emory University
Publications - 83
Citations - 3430
David S. Yu is an academic researcher from Emory University. The author has contributed to research in topics: DNA repair & DNA damage. The author has an hindex of 22, co-authored 68 publications receiving 2894 citations. Previous affiliations of David S. Yu include University of Virginia & Northwestern University.
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Journal ArticleDOI
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex
Luca Pellegrini,David S. Yu,Thomas Lo,Shubha Anand,Miyoung Lee,Tom L. Blundell,Ashok R. Venkitaraman +6 more
TL;DR: The BRC repeat mimics a motif in RAD51 that serves as an interface for oligomerization between individual RAD51 monomers, thus enabling BRCA2 to control the assembly of the RAD51 nucleoprotein filament, which is essential for strand-pairing reactions during DNA recombination.
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EMSY Links the BRCA2 Pathway to Sporadic Breast and Ovarian Cancer
Luke Hughes-Davies,David G. Huntsman,Margarida Ruas,Francois Fuks,Jacqueline M. Bye,Suet-Feung Chin,Jonathon Milner,Lindsay Brown,Forrest D. Hsu,Blake Gilks,Torsten O. Nielsen,Michael Schulzer,Stephen Chia,Joseph Ragaz,Anthony P. Cahn,Lori Linger,Hilal Özdağ,Elena Cattaneo,Ekaterina S. Jordanova,Ed Schuuring,David S. Yu,Ashok R. Venkitaraman,Bruce A.J. Ponder,Aidan J. Doherty,Samuel Aparicio,David Bentley,Charles Theillet,Chris P. Ponting,Carlos Caldas,Tony Kouzarides +29 more
TL;DR: It is shown that the EMSY gene is amplified almost exclusively in sporadic breast cancer and higher-grade ovarian cancer, and its amplification is associated with worse survival, particularly in node-negative breast cancer, suggesting that it may be of prognostic value.
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Full‐length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2
David S. Shin,Luca Pellegrini,Douglas S. Daniels,Biana Yelent,Lisa Craig,Debbie Bates,David S. Yu,Mahmud K.K. Shivji,Chiharu Hitomi,Andrew S. Arvai,Niels Volkmann,Hiro Tsuruta,Tom L. Blundell,Ashok R. Venkitaraman,John A. Tainer +14 more
TL;DR: Both BRCA2 and RAD54 may act as antagonists and chaperones for RAD51 filament assembly by coupling RAD51 interface exchanges with DNA binding, and an interface exchange hypothesis for coordinated protein interactions in homologous recombination is supported.
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Ultrasound GLCM texture analysis of radiation-induced parotid-gland injury in head-and-neck cancer radiotherapy: an in vivo study of late toxicity.
Xiaofeng Yang,Srini Tridandapani,Jonathan J. Beitler,David S. Yu,Emi J. Yoshida,Walter J. Curran,Tian Liu +6 more
TL;DR: The authors have demonstrated the feasibility of ultrasonic texture evaluation of parotid glands; and the sonographic features may serve as imaging signatures to assess radiation-induced parotids injury after head-and-neck radiotherapy.
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A FancD2-Monoubiquitin Fusion Reveals Hidden Functions of Fanconi Anemia Core Complex in DNA Repair
Nobuko Matsushita,Hiroyuki Kitao,Masamichi Ishiai,Naoki Nagashima,Seiki Hirano,Katsuya Okawa,Tomohiko Ohta,David S. Yu,Peter J. McHugh,Ian D. Hickson,Ashok R. Venkitaraman,Hitoshi Kurumizaka,Minoru Takata +12 more
TL;DR: It is shown that a chicken FancD2-ubiquitin fusion protein, carrying a Lys-Arg substitution removing the natural monoubiquitination site (D2KR-Ub), could reverse cisplatin hypersensitivity and localize to chromatin in FANCD2-deficient DT40 cells.